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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2000-1-24
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pubmed:abstractText |
It is thought as a consequence of continuous replication, HIV-1 has acquired an optimal fitness state and that suboptimal antiretroviral therapy selects for drug resistant variants which show impaired fitness in the absence of the drug. In this paper we studied the evolution and fitness of viral populations appearing in a patient who received protease monotherapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0269-9370
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2349-59
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10597776-Amino Acid Sequence,
pubmed-meshheading:10597776-Base Sequence,
pubmed-meshheading:10597776-DNA Primers,
pubmed-meshheading:10597776-Drug Resistance, Microbial,
pubmed-meshheading:10597776-Genetic Variation,
pubmed-meshheading:10597776-HIV Infections,
pubmed-meshheading:10597776-HIV Protease,
pubmed-meshheading:10597776-HIV Protease Inhibitors,
pubmed-meshheading:10597776-HIV-1,
pubmed-meshheading:10597776-Humans,
pubmed-meshheading:10597776-Mutation,
pubmed-meshheading:10597776-Phylogeny,
pubmed-meshheading:10597776-Ritonavir,
pubmed-meshheading:10597776-Time Factors,
pubmed-meshheading:10597776-Virulence,
pubmed-meshheading:10597776-Virus Replication
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pubmed:year |
1999
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pubmed:articleTitle |
Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy.
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pubmed:affiliation |
Eijkman-Winkler Institute, Department of Virology, University Hospital Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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