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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5446
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pubmed:dateCreated |
1999-12-16
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pubmed:abstractText |
Linker proteins function as molecular scaffolds to localize enzymes with substrates. In B cells, B cell linker protein (BLNK) links the B cell receptor (BCR)-activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo role of BLNK, mice deficient in BLNK were generated. B cell development in BLNK-/- mice was blocked at the transition from B220+CD43+ progenitor B to B220+CD43- precursor B cells. Only a small percentage of immunoglobulin M++ (IgM++), but not mature IgMloIgDhi, B cells were detected in the periphery. Hence, BLNK is an essential component of BCR signaling pathways and is required to promote B cell development.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
286
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1949-54
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10583957-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10583957-Aging,
pubmed-meshheading:10583957-Animals,
pubmed-meshheading:10583957-B-Lymphocyte Subsets,
pubmed-meshheading:10583957-B-Lymphocytes,
pubmed-meshheading:10583957-Bone Marrow Cells,
pubmed-meshheading:10583957-Carrier Proteins,
pubmed-meshheading:10583957-Cell Count,
pubmed-meshheading:10583957-Cell Differentiation,
pubmed-meshheading:10583957-Cell Separation,
pubmed-meshheading:10583957-Cell Size,
pubmed-meshheading:10583957-Flow Cytometry,
pubmed-meshheading:10583957-Gene Targeting,
pubmed-meshheading:10583957-Hematopoietic Stem Cells,
pubmed-meshheading:10583957-Immunoglobulin M,
pubmed-meshheading:10583957-Leukopoiesis,
pubmed-meshheading:10583957-Lymphoid Tissue,
pubmed-meshheading:10583957-Mice,
pubmed-meshheading:10583957-Mice, Inbred C57BL,
pubmed-meshheading:10583957-Phosphoproteins,
pubmed-meshheading:10583957-Receptors, Antigen, B-Cell,
pubmed-meshheading:10583957-Second Messenger Systems,
pubmed-meshheading:10583957-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
Requirement for B cell linker protein (BLNK) in B cell development.
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pubmed:affiliation |
Center for Immunology, Division of Rheumatology, Department of Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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