Linked Life Data

10582704

Source:http://linkedlifedata.com/resource/pubmed/id/10582704

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1999-12-14
pubmed:abstractText
Bone morphogenetic protein (BMP-6, also known as vegetal-pale-gene-related and decaplentaplegic-vegetal-related) is a member of the transforming growth factor-beta superfamily of multifunctional signaling molecules. BMP-6 appears to play various biological roles in developing tissues, including regulation of epithelial differentiation. To study the possible involvement of BMP-6 in normal and neoplastic human salivary glands, we compared its mRNA and protein expression in 4 fetal and 15 adult salivary glands and in 22 benign and 32 malignant salivary gland tumors. In situ hybridization and Northern blot analysis indicated that BMP-6 transcripts are expressed at low levels in acinar cells of adult submandibular glands but not in ductal or stromal cells. BMP-6 was immunolocated specifically in serous acini of parotid and submandibular glands. None was found in primitive fetal acini or any other types of cell in adult salivary glands, including mucous acini and epithelial cells of intercalated, striated, and excretory ducts. All 16 cases of acinic cell carcinoma consistently exhibited cytoplasmic BMP-6 staining in the acinar tumor cells. Other cell types in these tumors, including intercalated duct-like cells, clear, vacuolated cells, and nonspecific glandular cells, exhibited no cytoplasmic BMP-6 staining. Other benign and malignant salivary gland tumors lacked BMP-6 immunoreactivity, except in areas of squamous differentiation. The results indicate that in salivary glands, BMP-6 expression is uniquely associated with acinar cell differentiation and suggest that BMP-6 may play a role in salivary gland function. More importantly, our experience of differential diagnostic problems related to salivary gland tumors suggests that the demonstration of consistent and specific BMP-6 immunoreactivity in acinic cell carcinoma is likely to be of clinical value.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5815-21
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10582704-Adenolymphoma, pubmed-meshheading:10582704-Adenoma, pubmed-meshheading:10582704-Adult, pubmed-meshheading:10582704-Aged, pubmed-meshheading:10582704-Aged, 80 and over, pubmed-meshheading:10582704-Blotting, Northern, pubmed-meshheading:10582704-Bone Morphogenetic Protein 6, pubmed-meshheading:10582704-Bone Morphogenetic Proteins, pubmed-meshheading:10582704-Carcinoma, pubmed-meshheading:10582704-Cell Differentiation, pubmed-meshheading:10582704-Female, pubmed-meshheading:10582704-Fetus, pubmed-meshheading:10582704-Humans, pubmed-meshheading:10582704-Male, pubmed-meshheading:10582704-Middle Aged, pubmed-meshheading:10582704-Neoplasm Proteins, pubmed-meshheading:10582704-RNA, Messenger, pubmed-meshheading:10582704-Salivary Gland Neoplasms, pubmed-meshheading:10582704-Salivary Glands
pubmed:year
1999
pubmed:articleTitle
Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland.
pubmed:affiliation
Institute of Dentistry, University of Turku, Finland. heikinhe@netlife.fi
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't