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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1999-12-10
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pubmed:abstractText |
The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from five individuals with motor-complete spinal cord injury ([SCI] four men and one woman aged 31 to 50 years, 3 to 25 years postinjury involving C5-T8). Western blot analysis indicated that GLUT-1 increased by 52% and GLUT-4 increased by 72% with training (P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0026-0495
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1409-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10582549-Adult,
pubmed-meshheading:10582549-Biopsy,
pubmed-meshheading:10582549-Blotting, Western,
pubmed-meshheading:10582549-Citrate (si)-Synthase,
pubmed-meshheading:10582549-Electric Stimulation Therapy,
pubmed-meshheading:10582549-Exercise Therapy,
pubmed-meshheading:10582549-Female,
pubmed-meshheading:10582549-Glucose Tolerance Test,
pubmed-meshheading:10582549-Glucose Transporter Type 1,
pubmed-meshheading:10582549-Glucose Transporter Type 4,
pubmed-meshheading:10582549-Humans,
pubmed-meshheading:10582549-Male,
pubmed-meshheading:10582549-Middle Aged,
pubmed-meshheading:10582549-Monosaccharide Transport Proteins,
pubmed-meshheading:10582549-Muscle, Skeletal,
pubmed-meshheading:10582549-Muscle Proteins,
pubmed-meshheading:10582549-Oxidation-Reduction,
pubmed-meshheading:10582549-Paralysis
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pubmed:year |
1999
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pubmed:articleTitle |
Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle.
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pubmed:affiliation |
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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