rdf:type |
|
lifeskim:mentions |
umls-concept:C0001975,
umls-concept:C0003232,
umls-concept:C0005576,
umls-concept:C0018270,
umls-concept:C0030827,
umls-concept:C0150312,
umls-concept:C0995740,
umls-concept:C1280500,
umls-concept:C1334905,
umls-concept:C1417812,
umls-concept:C1512899
|
pubmed:issue |
4
|
pubmed:dateCreated |
1999-12-9
|
pubmed:abstractText |
Growth of Streptomyces clavuligerus NP1 in the presence of methanol or ethanol resulted in a marked increase in production of cephalosporin(s) from penicillin G by resting cells. The mycelium produced in alcohol-supplemented medium was fragmented and dispersed as compared with growth in control medium. HPLC analysis showed that at least two products were present in the biotransformation supernatant fluid after 1 h incubation. One of them has been identified as deacetoxycephalosporin G (DAOG).
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0175-7598
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
52
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
484-8
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10570794-Alcohols,
pubmed-meshheading:10570794-Biotransformation,
pubmed-meshheading:10570794-Cephalosporins,
pubmed-meshheading:10570794-Chromatography, High Pressure Liquid,
pubmed-meshheading:10570794-Culture Media,
pubmed-meshheading:10570794-Ethanol,
pubmed-meshheading:10570794-Methanol,
pubmed-meshheading:10570794-Penicillin G,
pubmed-meshheading:10570794-Penicillins,
pubmed-meshheading:10570794-Streptomyces,
pubmed-meshheading:10570794-Time Factors
|
pubmed:year |
1999
|
pubmed:articleTitle |
Stimulatory effect of growth in the presence of alcohols on biotransformation of penicillin G into cephalosporin-type antibiotics by resting cells of Streptomyces clavuligerus NP1.
|
pubmed:affiliation |
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|