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rdf:type |
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lifeskim:mentions |
umls-concept:C0012632,
umls-concept:C0015576,
umls-concept:C0025663,
umls-concept:C0033684,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0871161,
umls-concept:C0872053,
umls-concept:C1552599,
umls-concept:C1704222,
umls-concept:C1704787
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pubmed:dateCreated |
1999-12-6
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pubmed:abstractText |
Methods for the selection and characterization of antisense oligonucleotides for specifically eliminating closely related gene family members are available. High-throughput semiautomated methods using 96-well plate formats and array technology and improved assays are under active development that will streamline many steps and will likely merge. Second-generation 20-mer antisense phosphorothioate oligonucleotides containing 2'-methoxyethyl groups at the first and last 6 nucleotides with improved nuclease resistance and RNA affinity are becoming available.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 10,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Thionucleotides
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pubmed:status |
MEDLINE
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pubmed:issn |
0076-6879
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
314
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
342-62
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10565024-Animals,
pubmed-meshheading:10565024-Cell Transformation, Neoplastic,
pubmed-meshheading:10565024-Gene Expression,
pubmed-meshheading:10565024-Half-Life,
pubmed-meshheading:10565024-Isoenzymes,
pubmed-meshheading:10565024-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10565024-Liposomes,
pubmed-meshheading:10565024-Mice,
pubmed-meshheading:10565024-Mice, Knockout,
pubmed-meshheading:10565024-Mitogen-Activated Protein Kinase 10,
pubmed-meshheading:10565024-Mitogen-Activated Protein Kinase 9,
pubmed-meshheading:10565024-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10565024-Multigene Family,
pubmed-meshheading:10565024-Oligonucleotides, Antisense,
pubmed-meshheading:10565024-Phenotype,
pubmed-meshheading:10565024-Protein Kinases,
pubmed-meshheading:10565024-Protein-Tyrosine Kinases,
pubmed-meshheading:10565024-Thionucleotides,
pubmed-meshheading:10565024-Transfection,
pubmed-meshheading:10565024-Transplantation, Heterologous
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pubmed:year |
2000
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pubmed:articleTitle |
Antisense methods for discrimination of phenotypic properties of closely related gene products: Jun kinase family.
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pubmed:affiliation |
Sidney Kimmel Cancer Center, San Diego, California 92121, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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