rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
8
|
pubmed:dateCreated |
1999-11-16
|
pubmed:abstractText |
The role of major histocompatibility complex class II antigens in hematopoiesis is not well defined. We have shown that in vitro depletion of HLA-DR+ cells from canine marrow (e.g., by anti-HLA-DR monoclonal antibody [mAb] H81.9 and complement) prevents hematopoietic recovery. In vivo administration of the same mAb H81.9 after transplantation of unmanipulated autologous marrow results in graft failure. In vitro mAb H81.9 inhibited colony formation from short-term and long-term marrow cultures.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0041-1337
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
27
|
pubmed:volume |
68
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1161-71
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:10551646-Animals,
pubmed-meshheading:10551646-Antibodies, Monoclonal,
pubmed-meshheading:10551646-Antigens, CD34,
pubmed-meshheading:10551646-Apoptosis,
pubmed-meshheading:10551646-Bone Marrow Cells,
pubmed-meshheading:10551646-Bone Marrow Transplantation,
pubmed-meshheading:10551646-Cell Line,
pubmed-meshheading:10551646-Cytokines,
pubmed-meshheading:10551646-Dogs,
pubmed-meshheading:10551646-Female,
pubmed-meshheading:10551646-HLA-DR Antigens,
pubmed-meshheading:10551646-Hematopoiesis,
pubmed-meshheading:10551646-Histocompatibility Antigens Class II,
pubmed-meshheading:10551646-Humans,
pubmed-meshheading:10551646-Male,
pubmed-meshheading:10551646-Postoperative Period,
pubmed-meshheading:10551646-Transplantation, Autologous
|
pubmed:year |
1999
|
pubmed:articleTitle |
Recognition of major histocompatibility complex class II antigens by two anti-HLA-DR monoclonal antibodies on canine marrow cells correlates with effects on in vitro and in vivo hematopoiesis.
|
pubmed:affiliation |
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|