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rdf:type |
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lifeskim:mentions |
umls-concept:C0011854,
umls-concept:C0017262,
umls-concept:C0030274,
umls-concept:C0030705,
umls-concept:C0185117,
umls-concept:C0205155,
umls-concept:C0253023,
umls-concept:C0333348,
umls-concept:C1522472,
umls-concept:C1539477,
umls-concept:C1551341,
umls-concept:C1552858,
umls-concept:C1552923,
umls-concept:C1552924,
umls-concept:C1705191,
umls-concept:C2911684
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pubmed:issue |
11
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pubmed:dateCreated |
1999-12-7
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pubmed:abstractText |
Type I (insulin-dependent) diabetes results mainly from T-cell-mediated autoimmune destruction of pancreatic beta cells. Cytotoxic T lymphocytes destroy target cells via a perforin-based or Fas-based mechanism. Our previous study indicated that the Fas-Fas ligand (FasL) pathway is required for the development of autoimmune diabetes in the NOD mouse. We now investigated whether or not the Fas-FasL system is involved in the beta-cell destruction in human Type I diabetes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0012-186X
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pubmed:author |
pubmed-author:HanafusaTT,
pubmed-author:ImagawaAA,
pubmed-author:ItohNN,
pubmed-author:IwahashiHH,
pubmed-author:MatsuzawaYY,
pubmed-author:MiyagawaJJ,
pubmed-author:MoriwakiMM,
pubmed-author:NagataSS,
pubmed-author:NakajimaHH,
pubmed-author:NambaMM,
pubmed-author:YamagataKK,
pubmed-author:YamamotoKK
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1332-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10550417-Adolescent,
pubmed-meshheading:10550417-Adult,
pubmed-meshheading:10550417-Antigens, CD95,
pubmed-meshheading:10550417-Diabetes Mellitus, Type 1,
pubmed-meshheading:10550417-Fas Ligand Protein,
pubmed-meshheading:10550417-Female,
pubmed-meshheading:10550417-Humans,
pubmed-meshheading:10550417-Immunohistochemistry,
pubmed-meshheading:10550417-In Situ Nick-End Labeling,
pubmed-meshheading:10550417-Inflammation,
pubmed-meshheading:10550417-Islets of Langerhans,
pubmed-meshheading:10550417-Male,
pubmed-meshheading:10550417-Membrane Glycoproteins,
pubmed-meshheading:10550417-Middle Aged,
pubmed-meshheading:10550417-Pancreas,
pubmed-meshheading:10550417-Phenotype
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pubmed:year |
1999
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pubmed:articleTitle |
Fas and Fas ligand expression in inflamed islets in pancreas sections of patients with recent-onset Type I diabetes mellitus.
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pubmed:affiliation |
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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