Linked Life Data

10546511

Source:http://linkedlifedata.com/resource/pubmed/id/10546511

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
41
pubmed:dateCreated
1999-12-10
pubmed:abstractText
Anticonvulsants with aromatic ring structure such as phenytoine, carbamazepine, phenobarbital and lamotrigine can induce a drug hypersensitivity syndrome ("anticonvulsant hypersensitivity syndrome", AHS). Though the incidence of AHS is low, correct and early diagnosis are crucial to stop further progression by immediately withholding the causative drug. AHS usually starts within the first 2-8 weeks after initiation of therapy with fever, followed over the next 1-2 days by a cutaneous reaction and lymphadenopathy. The skin reaction is usually exanthematous but can also manifest itself as Stevens-Johnson or Lyell syndrome. AHS is commonly associated with symptomatic or asymptomatic internal organ involvement usually affecting the liver, although haematologic, renal or pulmonary impairment may also occur. We report two cases illustrating the clinical course and discuss theories about the potential pathogenesis and the treatment of AHS.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1661-8157
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1660-6
pubmed:dateRevised
2008-6-10
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
[Anticonvulsant hypersensitivity syndrome. 2 case reports and an overview].
pubmed:affiliation
Medizinische Universitätsklinik A, Kantonsspital Basel.
pubmed:publicationType
Journal Article, English Abstract, Review, Case Reports