|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
44
|
|
pubmed:dateCreated |
1999-12-16
|
|
pubmed:abstractText |
Smads are signal transducers for members of the transforming growth factor-beta (TGF-beta) superfamily. Upon ligand stimulation, receptor-regulated Smads (R-Smads) are phosphorylated by serine/threonine kinase receptors, form complexes with common-partner Smad, and translocate into the nucleus, where they regulate the transcription of target genes together with other transcription factors. Polyomavirus enhancer binding protein 2/core binding factor (PEBP2/CBF) is a transcription factor complex composed of alpha and beta subunits. The alpha subunits of PEBP2/CBF, which contain the highly conserved Runt domain, play essential roles in hematopoiesis and osteogenesis. Here we show that three mammalian alpha subunits of PEBP2/CBF form complexes with R-Smads that act in TGF-beta/activin pathways as well as those acting in bone morphogenetic protein (BMP) pathways. Among them, PEBP2alphaC/CBFA3/AML2 forms a complex with Smad3 and stimulates transcription of the germline Ig Calpha promoter in a cooperative manner, for which binding of both factors to their specific binding sites is essential. PEBP2 may thus be a nuclear target of TGF-beta/BMP signaling.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Activin Receptors, Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/TGF-beta type I receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-2,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0021-9258
|
|
pubmed:author |
pubmed-author:ChenL FLF,
pubmed-author:FukuchiMM,
pubmed-author:GuoW HWH,
pubmed-author:HanaiJJ,
pubmed-author:ImamuraTT,
pubmed-author:IshidohTT,
pubmed-author:ItoYY,
pubmed-author:KannoTT,
pubmed-author:KawabataMM,
pubmed-author:KimV VVV,
pubmed-author:KimW YWY,
pubmed-author:MiyazonoKK,
pubmed-author:Ohtani-FujitaNN,
pubmed-author:StavnezerJJ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
29
|
|
pubmed:volume |
274
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
31577-82
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10531362-Activin Receptors, Type I,
pubmed-meshheading:10531362-Bone Morphogenetic Proteins,
pubmed-meshheading:10531362-DNA-Binding Proteins,
pubmed-meshheading:10531362-Germ Cells,
pubmed-meshheading:10531362-Immunoglobulins,
pubmed-meshheading:10531362-Promoter Regions, Genetic,
pubmed-meshheading:10531362-Protein Binding,
pubmed-meshheading:10531362-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10531362-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:10531362-Signal Transduction,
pubmed-meshheading:10531362-Smad3 Protein,
pubmed-meshheading:10531362-Trans-Activators,
pubmed-meshheading:10531362-Transcription Factor AP-2,
pubmed-meshheading:10531362-Transcription Factors,
pubmed-meshheading:10531362-Transcriptional Activation,
pubmed-meshheading:10531362-Transforming Growth Factor beta
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter.
|
|
pubmed:affiliation |
Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, 1-37-1 Kami-ikebukuro, Toshima-ku, Tokyo 70-8455, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
