|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1999-11-18
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|
pubmed:abstractText |
The, 3'-N-acyl-N-debenzoylpaclitaxel analogues 1a-d were synthesized and evaluated on biological systems. Some of the analogues 1a-d exhibited higher cytotoxicities (up to 20-fold) and stronger abilities to induce apoptosis than paclitaxel. In an in vivo experiment against i.p. implanted B16 melanoma, the most cytotoxic compound 1b in vitro caused tumor growth inhibition more than paclitaxel.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0968-0896
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
2115-9
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:10530962-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10530962-Apoptosis,
pubmed-meshheading:10530962-Cell Division,
pubmed-meshheading:10530962-HL-60 Cells,
pubmed-meshheading:10530962-Humans,
pubmed-meshheading:10530962-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10530962-Melanoma, Experimental,
pubmed-meshheading:10530962-Paclitaxel,
pubmed-meshheading:10530962-Spectrometry, Mass, Fast Atom Bombardment
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|
pubmed:year |
1999
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|
pubmed:articleTitle |
Synthesis and biology of 3'-N-acyl-N-debenzoylpaclitaxel analogues.
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|
pubmed:affiliation |
Life Sciences Division, Korea Institute of Science and Technology, Seoul, South Korea.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
