| pubmed-article:10522786 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10522786 | lifeskim:mentions | umls-concept:C0035870 | lld:lifeskim |
| pubmed-article:10522786 | lifeskim:mentions | umls-concept:C1123019 | lld:lifeskim |
| pubmed-article:10522786 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:10522786 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:10522786 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:10522786 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:10522786 | lifeskim:mentions | umls-concept:C0018014 | lld:lifeskim |
| pubmed-article:10522786 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10522786 | pubmed:dateCreated | 1999-12-3 | lld:pubmed |
| pubmed-article:10522786 | pubmed:abstractText | A comparison of the effect on the immune responses in gnotobiotic lambs was made between an iscom vaccine prepared from recombinant rotavirus VP6 protein, an inactivated rotavirus/iscom-matrix vaccine and a vaccine comprising inactivated rotavirus alone. All three vaccines induced immunological priming and some degree of protection was observed after a single oral dose. However, different immune responses were induced in response to a virulent infection. The group vaccinated with the rotavirus/iscom-matrix vaccine showed a Th2-like response characterised by rotavirus-specific antibodies and a down-regulation of IFNgamma in jejunal Peyer's patches. Both Th1-like and Th2-like immune responses were induced in the group receiving the VP6 vaccine as seen by significantly increased expressions of IFNgamma and IL-6 in the jejunal Peyer's patch together with an increased percentage of CD8+ T cells in the intestine and rotavirus-specific antibodies at mucosal surfaces. Iscom vaccines given orally have the ability to induce both Th1-like and Th2-like immune responses in a ruminant model. | lld:pubmed |
| pubmed-article:10522786 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10522786 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10522786 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10522786 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10522786 | pubmed:issn | 0165-2427 | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:MoreinBB | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:SnodgrassD... | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:CampbellII | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:WoodAA | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:ClarkeC JCJ | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:BruceM GMG | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:BellmanAA | lld:pubmed |
| pubmed-article:10522786 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:10522786 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10522786 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10522786 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:10522786 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10522786 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10522786 | pubmed:pagination | 53-67 | lld:pubmed |
| pubmed-article:10522786 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10522786 | pubmed:meshHeading | pubmed-meshheading:10522786... | lld:pubmed |
| pubmed-article:10522786 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10522786 | pubmed:articleTitle | Effect of oral rotavirus/iscom vaccines on immune responses in gnotobiotic lambs. | lld:pubmed |
| pubmed-article:10522786 | pubmed:affiliation | Moredun Research Institute, International Research Centre, Pentlands Science Park, Penicuik, Midlothian, UK. lpi@ssi.dk | lld:pubmed |
| pubmed-article:10522786 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10522786 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10522786 | lld:pubmed |
