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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-12-3
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pubmed:abstractText |
A comparison of the effect on the immune responses in gnotobiotic lambs was made between an iscom vaccine prepared from recombinant rotavirus VP6 protein, an inactivated rotavirus/iscom-matrix vaccine and a vaccine comprising inactivated rotavirus alone. All three vaccines induced immunological priming and some degree of protection was observed after a single oral dose. However, different immune responses were induced in response to a virulent infection. The group vaccinated with the rotavirus/iscom-matrix vaccine showed a Th2-like response characterised by rotavirus-specific antibodies and a down-regulation of IFNgamma in jejunal Peyer's patches. Both Th1-like and Th2-like immune responses were induced in the group receiving the VP6 vaccine as seen by significantly increased expressions of IFNgamma and IL-6 in the jejunal Peyer's patch together with an increased percentage of CD8+ T cells in the intestine and rotavirus-specific antibodies at mucosal surfaces. Iscom vaccines given orally have the ability to induce both Th1-like and Th2-like immune responses in a ruminant model.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Capsid Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ISCOMs,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/VP6 protein, Rotavirus,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Inactivated,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Vaccines
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0165-2427
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
53-67
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10522786-Administration, Oral,
pubmed-meshheading:10522786-Animals,
pubmed-meshheading:10522786-Antibodies, Viral,
pubmed-meshheading:10522786-Antibody Formation,
pubmed-meshheading:10522786-Antigens, Viral,
pubmed-meshheading:10522786-Capsid,
pubmed-meshheading:10522786-Capsid Proteins,
pubmed-meshheading:10522786-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:10522786-Flow Cytometry,
pubmed-meshheading:10522786-Germ-Free Life,
pubmed-meshheading:10522786-ISCOMs,
pubmed-meshheading:10522786-Interferon-gamma,
pubmed-meshheading:10522786-Jejunum,
pubmed-meshheading:10522786-Peyer's Patches,
pubmed-meshheading:10522786-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10522786-Rotavirus,
pubmed-meshheading:10522786-Rotavirus Infections,
pubmed-meshheading:10522786-Sheep,
pubmed-meshheading:10522786-Sheep Diseases,
pubmed-meshheading:10522786-T-Lymphocyte Subsets,
pubmed-meshheading:10522786-Vaccination,
pubmed-meshheading:10522786-Vaccines, Inactivated,
pubmed-meshheading:10522786-Viral Vaccines
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pubmed:year |
1999
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pubmed:articleTitle |
Effect of oral rotavirus/iscom vaccines on immune responses in gnotobiotic lambs.
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pubmed:affiliation |
Moredun Research Institute, International Research Centre, Pentlands Science Park, Penicuik, Midlothian, UK. lpi@ssi.dk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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