Linked Life Data

10517952

Source:http://linkedlifedata.com/resource/pubmed/id/10517952

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-11-22
pubmed:abstractText
Photoperiod is an environmental cue used by many temperate-zone species to regulate their reproductive timing. Within species, the degree of reproductive photoresponsiveness can vary widely both among and within populations. The neuroendocrine mechanisms causing this individual variation in photoresponsiveness are unknown. Using selected lines from a population of white-footed mice known to vary genetically in reproductive photoresponsiveness, we tested the hypothesis that variation in the number and/or location of melatonin receptors is the basis for individual differences in reproductive photoresponsiveness. The brains and pars tuberalis of the pituitary from sixteen mice, (eight mice from each of two lines selected for two generations to respond strongly or weakly to photoperiod), were processed for autoradiography using the radioligand 2-[125I]-iodomelatonin (IMEL). We found significantly higher specific IMEL binding in the medial preoptic area and the bed nucleus of the stria terminalis of non-responsive mice than responsive mice. There were no differences between groups in specific IMEL binding in the suprachiasmatic and dorsomedial nuclei of the hypothalamus, pars tuberalis, or paraventricular nucleus of the thalamus. These results provide support for the hypothesis that individual variation in photoresponsiveness is due in part to differences in the density or affinity of melatonin receptors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
4
pubmed:volume
840
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
56-64
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Differences in hypothalamic 2-[125I]iodomelatonin binding in photoresponsive and non-photoresponsive white-footed mice, Peromyscus leucopus.
pubmed:affiliation
Department of Biology, The College of William and Mary, Williamsburg, VA, USA. heideman@wm.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't