Source:http://linkedlifedata.com/resource/pubmed/id/10516269
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4 Pt 2
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pubmed:dateCreated |
1999-11-17
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pubmed:abstractText |
Recent studies of glutamate transporters in the central nervous system indicate that in addition to their fundamental role in mediating neurotransmitter uptake, these proteins may contribute to the modulation of a variety of cellular processes. Activation of the excitatory amino acid (EAA) carriers generates an electrogenic current attibutable to ion-coupled cotransport. In addition to this transport-associated current, a substrate-gated thermodynamically uncoupled anion flux has been identified that has been proposed to dampen neuronal excitability. Arachidonic acid has been reported to modulate a variety of membrane proteins involved in cellular signaling. Here we discuss recent findings that indicate arachidonic acid stimulates a previously uncharacterized proton-selective conductance in the Purkinje cell-specific subtype, EAAT4. The unique channel-like porperties of the EAATs, their unexpected localization, and physiological evidence propose a modulatory role for the EAATs in neuronal signaling and suggest a broader role for glutamate transporters than simply the clearance of synaptically released glutamate. Thus, the identification of this arachidonate-stimulated proton conductance extends the complexity of mechanisms through which glutamate transporters modulate neuronal excitability.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Transport System X-AG,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Transport Systems,
http://linkedlifedata.com/resource/pubmed/chemical/Arachidonic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamate Plasma Membrane...,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Protons,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Symporters
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
F481-6
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:10516269-Amino Acid Transport System X-AG,
pubmed-meshheading:10516269-Amino Acid Transport Systems,
pubmed-meshheading:10516269-Animals,
pubmed-meshheading:10516269-Arachidonic Acid,
pubmed-meshheading:10516269-Carrier Proteins,
pubmed-meshheading:10516269-Electric Conductivity,
pubmed-meshheading:10516269-Glutamate Plasma Membrane Transport Proteins,
pubmed-meshheading:10516269-Ion Channels,
pubmed-meshheading:10516269-Protons,
pubmed-meshheading:10516269-Receptors, Glutamate,
pubmed-meshheading:10516269-Symporters
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pubmed:year |
1999
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pubmed:articleTitle |
Functional diversity of excitatory amino acid transporters: ion channel and transport modes.
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pubmed:affiliation |
Howard Hughes Medical Institute, Vollum Institute for Advanced Biomedical Research, Portland, Oregon 97201, USA.
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pubmed:publicationType |
Journal Article,
Review
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