rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
9
|
pubmed:dateCreated |
1999-11-24
|
pubmed:abstractText |
The inhibitory effects of the hybrid liposomes on the growth of B-16 melanoma cells in vitro and in vivo were examined. The 50% inhibitory concentration of the hybrid liposomes composed of 90 mol% dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylenedodecyl ether (C12(EO)10) was one-twelfth of that of DMPC liposomes. It was noteworthy that for the first time significantly prolonged survival was obtained using a mouce model of carcinoma after the administration of the hybrid liposomes of 90 mol% DMPC/10 mol% C12(EO)n (n=10 or 23) without antitumor drugs.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0918-6158
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
22
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1013-4
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10513636-Animals,
pubmed-meshheading:10513636-Antineoplastic Agents,
pubmed-meshheading:10513636-Dimyristoylphosphatidylcholine,
pubmed-meshheading:10513636-Drug Screening Assays, Antitumor,
pubmed-meshheading:10513636-Liposomes,
pubmed-meshheading:10513636-Melanoma, Experimental,
pubmed-meshheading:10513636-Mice,
pubmed-meshheading:10513636-Neoplasm Transplantation,
pubmed-meshheading:10513636-Polyethylene Glycols,
pubmed-meshheading:10513636-Rats,
pubmed-meshheading:10513636-Tumor Cells, Cultured
|
pubmed:year |
1999
|
pubmed:articleTitle |
Chemotherapy with hybrid liposomes for melanomatosis.
|
pubmed:affiliation |
Graduate Course of Applied Chemistry, Kumamoto Institute of Technology, Japan.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|