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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021761,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0185117,
umls-concept:C0221099,
umls-concept:C0439097,
umls-concept:C0524892,
umls-concept:C0678226,
umls-concept:C1527148,
umls-concept:C1547348,
umls-concept:C1552644,
umls-concept:C1705241,
umls-concept:C1823153,
umls-concept:C2349976,
umls-concept:C2911684
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pubmed:issue |
7
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pubmed:dateCreated |
1999-11-4
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pubmed:abstractText |
Mice lacking the interleukin 7 receptor (IL-7R) generate alpha/beta T cells at a detectable but greatly reduced rate, but gamma/delta T cells are completely absent. The special role of IL-7R signaling in gamma/delta T cell development has remained unclear. IL-7Ralpha(-/-) mice exhibit a paucity of gamma gene rearrangements. This striking observation can be explained by a defect in T cell receptor (TCR)-gamma gene rearrangement, a defect in TCR-gamma gene transcription leading to death of gamma/delta lineage cells, and/or a requirement for IL-7R in commitment of cells to the gamma/delta lineage. To determine the role of IL-7R signaling in gamma/delta T cell development, we examined transcription of a prerearranged TCR-gamma transgene in IL-7Ralpha(-/-) mice, as well as the effects of IL-7 on transcription of endogenous, rearranged TCR-gamma genes in alpha/beta lineage cells. The results demonstrate that IL-7R-mediated signals are necessary for the normal expression of rearranged TCR-gamma genes. Equally significant, the results show that the poor expression of TCR-gamma genes in IL-7Ralpha(-/-) mice is responsible for the selective deficit in gamma/delta cells in these mice, since a high copy TCR-gamma transgene exhibited sufficient residual expression in IL-7Ralpha(-/-) mice to drive gamma/delta cell development. The results indicate that the absence of gamma/delta T cells in IL-7Ralpha(-/-) mice is due to insufficient TCR-gamma gene expression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-10098325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-10477551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-1372556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-1968227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-1992471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-2006158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-2326267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-2831066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-3486721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7481767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7481769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7589149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7686307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7697543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7699333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7719938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7831294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-7964471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8095954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8245791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8415665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8608586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8657137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8691145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8692964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8717521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8777722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8805634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-8976198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-9190924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-9215624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-9215626,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-9334367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-9393859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-9586633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10510087-9655485
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
190
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
973-82
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10510087-Animals,
pubmed-meshheading:10510087-Flow Cytometry,
pubmed-meshheading:10510087-Gene Expression Regulation,
pubmed-meshheading:10510087-Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor,
pubmed-meshheading:10510087-Genes, T-Cell Receptor gamma,
pubmed-meshheading:10510087-Mice,
pubmed-meshheading:10510087-Mice, Knockout,
pubmed-meshheading:10510087-Mice, Transgenic,
pubmed-meshheading:10510087-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:10510087-Receptors, Interleukin-7,
pubmed-meshheading:10510087-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10510087-Signal Transduction,
pubmed-meshheading:10510087-Spleen,
pubmed-meshheading:10510087-T-Lymphocytes,
pubmed-meshheading:10510087-Thymus Gland,
pubmed-meshheading:10510087-Transcription, Genetic
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pubmed:year |
1999
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pubmed:articleTitle |
Defective development of gamma/delta T cells in interleukin 7 receptor-deficient mice is due to impaired expression of T cell receptor gamma genes.
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pubmed:affiliation |
Department of Molecular and Cell Biology and the Cancer Research Laboratory, Division of Immunology, University of California at Berkeley, Berkeley, California 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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