|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5437
|
|
pubmed:dateCreated |
1999-10-21
|
|
pubmed:abstractText |
In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot of an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of "tetanic" stimulation (<10 micrometers). A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism can account for the LTD induced by glutamate release.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
286
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
110-3
|
|
pubmed:dateRevised |
2007-3-19
|
|
pubmed:meshHeading |
pubmed-meshheading:10506556-Animals,
pubmed-meshheading:10506556-Dizocilpine Maleate,
pubmed-meshheading:10506556-Electric Stimulation,
pubmed-meshheading:10506556-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10506556-Excitatory Postsynaptic Potentials,
pubmed-meshheading:10506556-Glutamates,
pubmed-meshheading:10506556-Glutamic Acid,
pubmed-meshheading:10506556-Infrared Rays,
pubmed-meshheading:10506556-Lasers,
pubmed-meshheading:10506556-Microscopy, Video,
pubmed-meshheading:10506556-Neocortex,
pubmed-meshheading:10506556-Neuronal Plasticity,
pubmed-meshheading:10506556-Patch-Clamp Techniques,
pubmed-meshheading:10506556-Photolysis,
pubmed-meshheading:10506556-Pyramidal Cells,
pubmed-meshheading:10506556-Rats,
pubmed-meshheading:10506556-Rats, Sprague-Dawley,
pubmed-meshheading:10506556-Receptors, Glutamate,
pubmed-meshheading:10506556-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:10506556-Synapses,
pubmed-meshheading:10506556-Synaptic Transmission
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation.
|
|
pubmed:affiliation |
Max-Planck-Institute of Psychiatry, Kraepelinstrasse 2, 80804 Munich, Germany. dodt@mpipsykl.mpg.de
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
