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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1999-12-2
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pubmed:databankReference |
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pubmed:abstractText |
Recognition that mutation of the protein nephrin, encoded by the NPHS1 gene, singly results in the cellular alterations that result in foot process effacement, and nephrotic range proteinuria emphasizes the pivotal role that this protein plays in regulating glomerular filter integrity. This article reports the development of reagents necessary to study the biology of nephrin in mouse, and describes the initial characterization of the nephrin protein.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1481-91
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10504499-Age Factors,
pubmed-meshheading:10504499-Animals,
pubmed-meshheading:10504499-Animals, Newborn,
pubmed-meshheading:10504499-Blotting, Northern,
pubmed-meshheading:10504499-Cell Communication,
pubmed-meshheading:10504499-Cloning, Molecular,
pubmed-meshheading:10504499-DNA, Complementary,
pubmed-meshheading:10504499-Epithelial Cells,
pubmed-meshheading:10504499-Fluorescent Antibody Technique,
pubmed-meshheading:10504499-Gene Expression,
pubmed-meshheading:10504499-Intercellular Junctions,
pubmed-meshheading:10504499-Kidney Glomerulus,
pubmed-meshheading:10504499-Membrane Proteins,
pubmed-meshheading:10504499-Mice,
pubmed-meshheading:10504499-Mice, Inbred C57BL,
pubmed-meshheading:10504499-Microscopy, Electron,
pubmed-meshheading:10504499-Molecular Sequence Data,
pubmed-meshheading:10504499-Proteins,
pubmed-meshheading:10504499-RNA, Messenger,
pubmed-meshheading:10504499-Sequence Homology, Amino Acid,
pubmed-meshheading:10504499-Transcription, Genetic
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pubmed:year |
1999
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pubmed:articleTitle |
Nephrin localizes to the slit pore of the glomerular epithelial cell.
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pubmed:affiliation |
University of Michigan Medical School, 1560 Medical Science Research Building II, Ann Arbor 48109-0676, USA. lholzman@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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