Linked Life Data

10504057

Source:http://linkedlifedata.com/resource/pubmed/id/10504057

Statements in which the resource exists.
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pubmed-article:10504057pubmed:abstractTextIt was recently demonstrated that interleukin-8 (IL-8) is produced by cultured melanoma cells and acts as an essential autocrine growth factor. Earlier studies from our laboratory demonstrated a direct correlation between IL-8 expression in human variant cell lines and their metastatic potential in nude mice. In the present study we examined the expression of IL-8 in human malignant melanomas using immunohistochemistry to correlate IL-8 levels with disease stage. None of the radial growth phase (RGP) tumours (melanoma in situ) expressed IL-8. In contrast, 50% of the vertical growth phase (VGP) tumours (invasive melanoma), which have a high risk of metastasis, showed IL-8 immunoreactivity. Further, all the metastatic lesions analysed showed intense staining for IL-8; the levels were higher than those observed in the primary skin tumours. In summary, the data suggest an association between the expression of IL-8 and the metastatic phenotype.lld:pubmed
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pubmed-article:10504057pubmed:authorpubmed-author:SinghR KRKlld:pubmed
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pubmed-article:10504057pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:10504057pubmed:articleTitleExpression of interleukin-8 in primary and metastatic malignant melanoma of the skin.lld:pubmed
pubmed-article:10504057pubmed:affiliationDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5660, USA. rsingh@unmc.edulld:pubmed
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