Linked Life Data

10494076

Source:http://linkedlifedata.com/resource/pubmed/id/10494076

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-11-18
pubmed:abstractText
Prior to the onset of hearing, synchronous cellular, neuronal, and morphogenetic processes participate in the development of a functional cochlea. We have studied the expression of different splice forms of trkB and trkC as well as p75(NGFR) in rat and mouse cochlea within this critical developmental period, using in situ hybridization, PCR, Northern blotting, and immunohistochemical analyses. An antibody to full-length trkB receptors proved to detect full-length trkB receptors as well as truncated trkB.T2 but not trkB. T1 isoforms. Full-length trkB and trkC isoforms as well as trkB.T2 but not trkB.T1 receptors were noted in cochlear neurons. A transient expression of trkB.T1 and trkB.T2 was observed at the epithelial-mesenchymal border of the spiral ligament during this time. A sequential appearance of trkB.T1, the low-affinity neurotrophin receptor p75(NGFR), and trkB.T2 in epithelial cochlear cells correlated with the formation of the inner sulcus of the organ. A differential expression of presumptive trkB.T2 in hair and supporting cells was observed concomitant with the maturation of the distinct innervation pattern of these cells. A gradual shift from p75(NGFR) to truncated trkC receptors in Pillar cells occurred during the formation of the tunnel of Corti. A distinct expression of full-length trkC correlated with the time of differentiation of the stria vascularis. Finally, an expression of trkB.T1 and trkB.T2 in oligodendrocytes, full-length trkB and trkC in nerve fibers, and p75(NGFR) in Schwann cells was noted at the glial interface of the VIIIth nerve during the establishment of the glial transition zone. These various transitory neurotrophin receptor expression patterns, which were related to final maturation processes of the cochlea, may provide new insights into the as yet obscure role of neurotrophin receptors in nonneuronal tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9967
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
414
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
33-49
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Differential expression of trkB.T1 and trkB.T2, truncated trkC, and p75(NGFR) in the cochlea prior to hearing function.
pubmed:affiliation
University of Tübingen, Department of Oto-Rhino-Laryngology, D-72076 Tübingen, Germany.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't