Source:http://linkedlifedata.com/resource/pubmed/id/10484511
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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0017127,
umls-concept:C0017687,
umls-concept:C0021641,
umls-concept:C0030685,
umls-concept:C0061355,
umls-concept:C0070358,
umls-concept:C0086418,
umls-concept:C0205208,
umls-concept:C0391871,
umls-concept:C0439834,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1419178,
umls-concept:C1963578
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pubmed:issue |
3 Pt 2
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pubmed:dateCreated |
1999-10-18
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pubmed:abstractText |
The aim of the present study was to assess the effect of glucagon-like peptide-1 (GLP-1) on solid gastric emptying and the subsequent release of pancreatic and intestinal hormones. In eight men [age 33.6 +/- 2.5 yr, body mass index 24.1 +/- 0.9 (means +/- SE)], scintigraphic solid gastric emptying during infusion of GLP-1 (0.75 pmol. kg(-1). min(-1)) or saline was studied for 180 min. Concomitantly, plasma concentrations of C- and N-terminal GLP-1, glucose, insulin, C-peptide, glucagon, and peptide YY (PYY) were assessed. Infusion of GLP-1 resulted in a profound inhibition of both the lag phase (GLP-1: 91.5, range 73.3-103.6 min vs. saline: 19. 5, range 10.2-43.4 min) and emptying rate (GLP-1: 0.34, range 0.06-0. 56 %/min vs. saline: 0.84, range 0.54-1.33 %/min; P < 0.01 for both) of solid gastric emptying. Concentrations of both intact and total GLP-1 were elevated to supraphysiological levels. Plasma glucose and glucagon concentrations were below baseline during infusion of GLP-1 in contrast to saline infusion, where concentrations were elevated above baseline (both P < 0.001). The insulin and C-peptide responses were lower during infusion with GLP-1 than with saline (P < 0.004 and P < 0.001, respectively). Plasma PYY concentrations decreased below baseline during GLP-1 infusion in contrast to saline, where concentrations were elevated above baseline (P = 0.04). Infusion of GLP-1 inhibits solid gastric emptying with secondary effects on the release of insulin, C-peptide, and glucagon, resulting in lower plasma glucose concentrations. In addition, the release of PYY into the circulation is inhibited by GLP-1 infusion, suggesting a negative feedback of GLP-1 on the function of the L-cell.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon-Like Peptide 1,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide YY,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
277
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R910-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10484511-Adult,
pubmed-meshheading:10484511-Gastric Emptying,
pubmed-meshheading:10484511-Glucagon,
pubmed-meshheading:10484511-Glucagon-Like Peptide 1,
pubmed-meshheading:10484511-Humans,
pubmed-meshheading:10484511-Insulin,
pubmed-meshheading:10484511-Male,
pubmed-meshheading:10484511-Peptide Fragments,
pubmed-meshheading:10484511-Peptide YY,
pubmed-meshheading:10484511-Protein Precursors
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pubmed:year |
1999
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pubmed:articleTitle |
GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans.
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pubmed:affiliation |
Division of Surgery, Danderyd Hospital, Karolinska Institutet, SE-182 88, Stockholm, Sweden. Erik.Naslund@kir.ds.sll.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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