Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1999-10-12
pubmed:abstractText
Cytotoxic T lymphocyte (CTL) responses against the simian immunodeficiency virus (SIV) envelope and Gag proteins were monitored in a Mamu-A*01-positive rhesus macaque infected with SIVsmE660. Peripheral blood mononuclear cells (PBMC) cultured with synthetic peptides spanning the entire gp160 and Gag coding region recognized a total of three epitopes. One located in Gag was identified as the previously described Mamu-A*01-restricted p11cC-->M epitope (CTPYDINQM). The other two epitopes, designated p15m and p54m, were located in the gp160 envelope protein. Both were nine amino acids in length and were predicted to bind Mamu-A*01 because they contained proline and leucine residues at positions 3 and 9, respectively. Indeed, expression of this class I major histocompatibility complex molecule was required for target cell recognition by envelope-specific CD8(+) T cells directed against both epitopes. These Mamu-A*01-restricted epitopes in the SIV envelope will be useful for monitoring immune responses in vaccinated or infected animals.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-1711081, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2019773, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2431484, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2497065, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2784486, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-2786147, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-7511178, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-7521921, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-8067053, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-8717519, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-8794394, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9060675, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9345075, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9458122, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9516110, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9565629, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9565630, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9637523, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9883837, http://linkedlifedata.com/resource/pubmed/commentcorrection/10482552-9933172
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8035-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
The simian immunodeficiency virus envelope glycoprotein contains two epitopes presented by the Mamu-A*01 class I molecule.
pubmed:affiliation
Children's Research Institute, Children's Hospital, Inc., Department of Pediatrics, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.