pubmed-article:10479402 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10479402 | lifeskim:mentions | umls-concept:C0385242 | lld:lifeskim |
pubmed-article:10479402 | lifeskim:mentions | umls-concept:C0301896 | lld:lifeskim |
pubmed-article:10479402 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
pubmed-article:10479402 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:10479402 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
pubmed-article:10479402 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
pubmed-article:10479402 | pubmed:issue | 9 | lld:pubmed |
pubmed-article:10479402 | pubmed:dateCreated | 1999-10-21 | lld:pubmed |
pubmed-article:10479402 | pubmed:abstractText | Apo-2L is a new member of the tumour necrosis factor (TNF) family shown to induce apoptosis in a number of tumour cell lines. Apo-2L mRNA is expressed by numerous human tissues. Here we report that Apo-2L is expressed and utilized by human Natural Killer (NK) cells. NK cells were shown to express surface Apo-2L in response to interleukin 2 (IL-2) activation, and this response was restricted to the CD3(-)population of the NK cells. Apo-2L mRNA and intracellular Apo-2L were present in both CD3(-)and CD3(+)NK cells; however, increased expression in response to IL-2 was only observed in CD3(-)CD56(+)cells. Also, IL-2-activated NK cells were shown to utilize membrane-bound Apo-2L in mediating lysis of Jurkat cells. Furthermore, Apo-2L-induced apoptosis of Jurkat cells was more rapid than FasL-induced apoptosis, indicating an important and distinct role for Apo-2L in apoptotic cell destruction. In conclusion, we report that NK cells express Apo-2L and that IL-2 activated CD3(-)NK cells utilize the Apo-2L pathway in mediating target cell lysis. | lld:pubmed |
pubmed-article:10479402 | pubmed:language | eng | lld:pubmed |
pubmed-article:10479402 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:10479402 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10479402 | pubmed:month | Sep | lld:pubmed |
pubmed-article:10479402 | pubmed:issn | 1043-4666 | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:AshkenaziAA | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:EspevikTT | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:SundanAA | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:SteinkjerBB | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:NonstadUU | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:EgebergKK | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:HausAA | lld:pubmed |
pubmed-article:10479402 | pubmed:author | pubmed-author:JohnsenA CAC | lld:pubmed |
pubmed-article:10479402 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
pubmed-article:10479402 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10479402 | pubmed:volume | 11 | lld:pubmed |
pubmed-article:10479402 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10479402 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10479402 | pubmed:pagination | 664-72 | lld:pubmed |
pubmed-article:10479402 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:10479402 | pubmed:meshHeading | pubmed-meshheading:10479402... | lld:pubmed |
pubmed-article:10479402 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10479402 | pubmed:articleTitle | Regulation of APO-2 ligand/trail expression in NK cells-involvement in NK cell-mediated cytotoxicity. | lld:pubmed |
pubmed-article:10479402 | pubmed:affiliation | Department of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim, Norway. Ann-Charlotte.Johnsen@medisin.ntnu.no | lld:pubmed |
pubmed-article:10479402 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10479402 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:10479402 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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