Source:http://linkedlifedata.com/resource/pubmed/id/10479125
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
1999-11-8
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| pubmed:abstractText |
We examined human herpesvirus 8 (HHV-8) seroprevalence and seroincidence among 245 homosexual men from New York City (NYC) and Washington, DC (DC) who have been followed since 1982. An immunofluorescence assay measured antibodies to a latent HHV-8 nuclear antigen. Seroprevalence was 20.4% in 1982; seroincidence was approximately 15%/year during 1982-1983 but fell sharply thereafter. NYC men had a higher seroprevalence (odds ratio, 3.43; P<.001) and seroincidence (rate ratio, 2.13; P=.01) than DC men. Risk of Kaposi's sarcoma (KS) was increased in seropositive men (adjusted relative hazard, 3.58; P=.02). Among men who were seropositive for both human immunodeficiency virus type 1 and HHV-8, the 10-year cumulative risk of KS was 39%; time from coinfection to KS diagnosis ranged from 15 to 154 months (median, 63.5 months). This study shows an epidemic of HHV-8 among US homosexual men in the early 1980s that was associated with a high risk of developing KS.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
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| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
180
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1010-7
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10479125-Antibodies, Viral,
pubmed-meshheading:10479125-Comorbidity,
pubmed-meshheading:10479125-District of Columbia,
pubmed-meshheading:10479125-Follow-Up Studies,
pubmed-meshheading:10479125-HIV Infections,
pubmed-meshheading:10479125-HIV Seropositivity,
pubmed-meshheading:10479125-HIV-1,
pubmed-meshheading:10479125-Herpesviridae Infections,
pubmed-meshheading:10479125-Herpesvirus 8, Human,
pubmed-meshheading:10479125-Homosexuality, Male,
pubmed-meshheading:10479125-Humans,
pubmed-meshheading:10479125-Incidence,
pubmed-meshheading:10479125-Male,
pubmed-meshheading:10479125-New York City,
pubmed-meshheading:10479125-Odds Ratio,
pubmed-meshheading:10479125-Prevalence,
pubmed-meshheading:10479125-Risk Factors,
pubmed-meshheading:10479125-Sarcoma, Kaposi,
pubmed-meshheading:10479125-Time Factors
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Evidence for concurrent epidemics of human herpesvirus 8 and human immunodeficiency virus type 1 in US homosexual men: rates, risk factors, and relationship to Kaposi's sarcoma.
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| pubmed:affiliation |
Viral Epidemiology Branch, National Cancer Institute, EPS 8016, Rockville, MD 20852, USA. obrient@exchange.nih.gov obrient@exchange.nih.gov
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| pubmed:publicationType |
Journal Article
|