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pubmed-article:10472325pubmed:abstractTextIn a Phase I study replication-deficient adenovirus containing the herpes simplex virus (HSV) thymidine kinase (TK) gene (AdV-HSV-TK) was instilled intraperitoneally in patients with recurrent ovarian cancer. Patients were treated with Acyclovir (ACV) or Valacyclovir (VCV) as enzymatic substrates. The purpose of this study was to compare serum levels of ACV and VCV.lld:pubmed
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pubmed-article:10472325pubmed:articleTitleThymidine kinase (TK) gene therapy of solid tumors: valacyclovir facilitates outpatient treatment.lld:pubmed
pubmed-article:10472325pubmed:affiliationDepartment of Obstetrics and Gynecology, Freiburg University Medical Center, Germany.lld:pubmed
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