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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-10-8
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pubmed:abstractText |
Calcium-channel blockers (CCBs) reduce systolic blood pressure and stroke-related mortality in stroke-prone spontaneously hypertensive rats (SPSHR). Brain ischemia is associated with loss of intracellular antioxidants. Increased formation of oxygen radicals and oxidation of LDL may enhance arterial vasoconstriction by various mechanisms. CCBs that also exert antioxidative properties in vitro may therefore be particularly useful. To investigate such antioxidant effects in vivo, we determined several parameters of LDL oxidation in SPSHR treated with two 1,4-dihydropyridine-type (1,4-DHP) CCBs of different lipophilic properties and compared them with antioxidant-treated and untreated controls. We also tested whether these drugs decrease the formation of oxidation-specific epitopes in arteries.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,4-dihydropyridine,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Dihydropyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/lacidipine,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0039-2499
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pubmed:author |
pubmed-author:BianchiAA,
pubmed-author:CapizziR LRL,
pubmed-author:CapuzziD MDM,
pubmed-author:D'ArmientoF PFP,
pubmed-author:DonzelliRR,
pubmed-author:GodfraindTT,
pubmed-author:GonnellaJ SJS,
pubmed-author:ManciniMM,
pubmed-author:NapoliCC,
pubmed-author:PalinskiWW,
pubmed-author:PalumboGG,
pubmed-author:SalomoneSS,
pubmed-author:de NigrisFF
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1907-15
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10471444-Animals,
pubmed-meshheading:10471444-Antioxidants,
pubmed-meshheading:10471444-Apolipoproteins B,
pubmed-meshheading:10471444-Arteries,
pubmed-meshheading:10471444-Calcium Channel Blockers,
pubmed-meshheading:10471444-Cerebrovascular Disorders,
pubmed-meshheading:10471444-Dihydropyridines,
pubmed-meshheading:10471444-Epitopes,
pubmed-meshheading:10471444-Genetic Predisposition to Disease,
pubmed-meshheading:10471444-Immunohistochemistry,
pubmed-meshheading:10471444-Lipoproteins, LDL,
pubmed-meshheading:10471444-Male,
pubmed-meshheading:10471444-Oxidation-Reduction,
pubmed-meshheading:10471444-Rats,
pubmed-meshheading:10471444-Rats, Inbred SHR,
pubmed-meshheading:10471444-Rats, Inbred WKY,
pubmed-meshheading:10471444-Reference Values,
pubmed-meshheading:10471444-Vitamin E
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pubmed:year |
1999
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pubmed:articleTitle |
1,4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats.
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pubmed:affiliation |
Department of Medicine and Endocrinology, University of California-San Diego, La Jolla, USA. cnapoli@ucsd.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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