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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
9
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pubmed:dateCreated |
1999-11-9
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pubmed:abstractText |
Inhalation of adenosine 5'-monophosphate (AMP) causes bronchoconstriction in patients with asthma and in many patients with chronic obstructive pulmonary disease (COPD). In asthma, AMP-induced bronchoconstriction has been shown to be determined mainly by release of mast cell mediators, and possibly by vagal nerve stimulation, since oral terfenadine (H1-receptor antagonist) and inhaled ipratropium bromide (muscarinic receptor antagonist) both increase PC20AMP.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0954-7894
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1287-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10469040-Adenosine Monophosphate,
pubmed-meshheading:10469040-Aged,
pubmed-meshheading:10469040-Bronchoconstriction,
pubmed-meshheading:10469040-Bronchodilator Agents,
pubmed-meshheading:10469040-Cross-Over Studies,
pubmed-meshheading:10469040-Double-Blind Method,
pubmed-meshheading:10469040-Female,
pubmed-meshheading:10469040-Histamine H1 Antagonists,
pubmed-meshheading:10469040-Histamine Release,
pubmed-meshheading:10469040-Humans,
pubmed-meshheading:10469040-Ipratropium,
pubmed-meshheading:10469040-Lung Diseases, Obstructive,
pubmed-meshheading:10469040-Male,
pubmed-meshheading:10469040-Methacholine Chloride,
pubmed-meshheading:10469040-Middle Aged,
pubmed-meshheading:10469040-Respiratory Function Tests,
pubmed-meshheading:10469040-Smoking,
pubmed-meshheading:10469040-Terfenadine
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pubmed:year |
1999
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pubmed:articleTitle |
Protective effect of oral terfenadine and not inhaled ipratropium on adenosine 5'-monophosphate-induced bronchoconstriction in patients with COPD.
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pubmed:affiliation |
Department of Pulmonology, University Hospital Groningen, Groningen, The Netherlands.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
