Linked Life Data

10463072

Source:http://linkedlifedata.com/resource/pubmed/id/10463072

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-9-23
pubmed:abstractText
Three genomically distinct isoforms of RyR are now known. RyR1 homologue is the primary isoform in skeletal muscles, whereas in cardiac muscles it is RyR2 homologue. RyR3 homologue occurs ubiquitously in many cells, but the biological function is little known, partly because of its minuscule amount in mammalian cells. The difference among RyR isoforms may not be so great in CICR activity, in other words, in the interaction of RyR isoforms with Ca2+, adenine nucleotides and caffeine. Species specificity among RyR1 homologues may be more important in the apparent difference between RyR1 and RyR3 homologues. CICR is likely to be the dominant underlying mechanism for E-C coupling in the cardiac muscle and probably in cells other than the skeletal muscle where the significance of CICR is controversial in physiological contraction. In E-C coupling of skeletal muscle (DICR), the reciprocal tight interactions between DHPR and RyR1 are critically required. The alpha 1 subunit of DHPR was only the main target of our current interests in the interaction with RyR1; the involvement of auxiliary subunits of alpha 2/delta and beta subunits and their mutual interactions, however, are also important. DICR and CICR in RyR1 share common properties of stimulation by concentrated solutes and modulation by luminal calcium or Ca2+, suggesting that the main difference between the two Ca2+ release mechanisms may be in the gating mechanism of the channel. Further investigations are required to understand molecular interactions during E-C coupling.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0065-227X
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-64
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Ryanodine receptor isoforms in excitation-contraction coupling.
pubmed:affiliation
Department of Pharmacology, Juntendo University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article, Review