Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1999-10-5
pubmed:abstractText
Plasmodium falciparum malaria is an important cause of morbidity and mortality in children. Factors that determine the development of mild versus severe malaria are not fully understood. Since host-derived nitric oxide (NO) has antiplasmodial properties, we measured NO production and NO synthase (NOS) activity in peripheral blood mononuclear cells (PBMC) from healthy Gabonese children with a history of prior mild malaria (PMM) or prior severe malaria (PSM) caused by P. falciparum. The PMM group had significantly higher levels of NOS activity in freshly isolated PBMC and higher NO production and NOS activity in cultured PBMC. The investigation of NO-modulating cytokines (e.g., interleukin 12, gamma interferon, tumor necrosis factor alpha [TNF-alpha], and transforming growth factor beta1) as an explanation for differing levels of NOS activity revealed that plasma levels of TNF-alpha were significantly higher in the PSM group. Our results suggest that NOS/ NO and TNF-alpha are markers for prior disease severity and important determinants of resistance to malaria.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-1425913, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-1879941, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-1978068, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-1991487, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-1991968, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-2657427, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-2667356, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-6268661, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7507509, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7519365, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7520338, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7520469, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7650384, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7688028, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7729896, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7935762, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-7970876, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-8063424, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-8329024, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-8525289, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-8726465, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-8730311, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-8760809, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-8809229, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-9348307, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-9457101, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-9692171, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-9841857, http://linkedlifedata.com/resource/pubmed/commentcorrection/10456963-9848075
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4977-81
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria.
pubmed:affiliation
Department of Medicine, VA and Duke University Medical Centers, Durham, North Carolina, USA.
pubmed:publicationType
Journal Article