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rdf:type |
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lifeskim:mentions |
umls-concept:C0012860,
umls-concept:C0012929,
umls-concept:C0025251,
umls-concept:C0162772,
umls-concept:C0205263,
umls-concept:C0205349,
umls-concept:C0439097,
umls-concept:C0439472,
umls-concept:C1179517,
umls-concept:C1547348,
umls-concept:C1705241
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pubmed:issue |
2
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pubmed:dateCreated |
1999-9-2
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pubmed:abstractText |
Reactive oxygen species (ROS) have been implicated in the induction of acute pancreatitis. Mitochondria possess a distinct genome (mtDNA) that is more susceptible to ROS-induced damage than nuclear DNA (nDNA). The purpose of our study was to determine the effect of ROS on mitochondrial function and membrane potential (delta psi mt), to identify signal transduction mechanisms activated by ROS, and to quantify damage to mtDNA in an in vitro pancreatitis model.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0039-6060
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
148-55
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10455877-Animals,
pubmed-meshheading:10455877-Calcium,
pubmed-meshheading:10455877-DNA, Mitochondrial,
pubmed-meshheading:10455877-DNA Damage,
pubmed-meshheading:10455877-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10455877-MAP Kinase Kinase 4,
pubmed-meshheading:10455877-Membrane Potentials,
pubmed-meshheading:10455877-Mitochondria,
pubmed-meshheading:10455877-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:10455877-NF-kappa B,
pubmed-meshheading:10455877-Pancreas,
pubmed-meshheading:10455877-Protein Kinases,
pubmed-meshheading:10455877-Rats,
pubmed-meshheading:10455877-Reactive Oxygen Species,
pubmed-meshheading:10455877-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Mitochondrial DNA damage and altered membrane potential (delta psi) in pancreatic acinar cells induced by reactive oxygen species.
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pubmed:affiliation |
Department of Surgery, University of Texas Medical Branch, Galveston 77555-0533, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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