| pubmed-article:10455121 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10455121 | lifeskim:mentions | umls-concept:C0597361 | lld:lifeskim |
| pubmed-article:10455121 | lifeskim:mentions | umls-concept:C0058836 | lld:lifeskim |
| pubmed-article:10455121 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:10455121 | lifeskim:mentions | umls-concept:C0086168 | lld:lifeskim |
| pubmed-article:10455121 | lifeskim:mentions | umls-concept:C1705810 | lld:lifeskim |
| pubmed-article:10455121 | pubmed:issue | 35 | lld:pubmed |
| pubmed-article:10455121 | pubmed:dateCreated | 1999-9-30 | lld:pubmed |
| pubmed-article:10455121 | pubmed:abstractText | Dynamin plays a critical role in the membrane fission mechanism that mediates regulated endocytosis of many G protein-coupled receptors. In addition, dynamin is required for ligand-induced activation of mitogen-activated protein kinase by certain receptors, raising a general question about the role of dynamin in mitogenic signal transduction. Here we report that endocytosis of mu and delta opioid receptors is not required for efficient ligand-induced activation of mitogen-activated protein kinase. Nevertheless, mitogenic signaling mediated by these receptors is specifically dynamin-dependent. Thus a functional role of dynamin in mitogenic signaling can be dissociated from its role in receptor-mediated endocytosis, suggesting a previously unidentified and distinct role of dynamin in signal transduction by certain G protein-coupled receptors. | lld:pubmed |
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| pubmed-article:10455121 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10455121 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10455121 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10455121 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10455121 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10455121 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10455121 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:10455121 | pubmed:author | pubmed-author:von ZastrowMM | lld:pubmed |
| pubmed-article:10455121 | pubmed:author | pubmed-author:WhistlerJ LJL | lld:pubmed |
| pubmed-article:10455121 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10455121 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:10455121 | pubmed:volume | 274 | lld:pubmed |
| pubmed-article:10455121 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10455121 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10455121 | pubmed:pagination | 24575-8 | lld:pubmed |
| pubmed-article:10455121 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:10455121 | pubmed:meshHeading | pubmed-meshheading:10455121... | lld:pubmed |
| pubmed-article:10455121 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10455121 | pubmed:articleTitle | Dissociation of functional roles of dynamin in receptor-mediated endocytosis and mitogenic signal transduction. | lld:pubmed |
| pubmed-article:10455121 | pubmed:affiliation | Department of Psychiatry, Program in Cell Biology, University of California, San Francisco, California 94143-0984, USA. | lld:pubmed |
| pubmed-article:10455121 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10455121 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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