Linked Life Data

10454487

Source:http://linkedlifedata.com/resource/pubmed/id/10454487

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-9-21
pubmed:abstractText
Baseline nociception and opioid antinociception were compared in male and ovariectomized female rhesus monkeys. Females were studied without estradiol replacement or during treatment with estradiol benzoate at doses (0.002 and 0.01 mg/kg/day) designed to mimic 17beta-estradiol blood levels observed during different phases of the menstrual cycle and during pregnancy. Baseline sensitivity to thermal stimuli (42-54 degrees C) was similar in male and ovariectomized female monkeys. The antinociceptive effects of the mu-opioid agonists fentanyl, morphine, butorphanol, and nalbuphine were examined at 50 and 54 degrees C. There were no sex-related differences in the antinociceptive effects of the high-efficacy mu agonist fentanyl; however, the lower-efficacy mu agonists morphine, butorphanol, and nalbuphine produced greater antinociceptive effects in males than in untreated ovariectomized females. Because butorphanol and nalbuphine have low selectivity for mu versus kappa receptors and may produce kappa-agonist effects under some conditions, the high-efficacy, kappa-selective agonist U50,488 was also studied. U50,488 also produced greater antinociceptive effects in males. Treatment with estradiol benzoate tended to enhance opioid antinociception in the ovariectomized females; however, this effect was significant only for butorphanol and U50,488 during treatment with the highest dose of estradiol benzoate. These findings suggest that opioid agonists usually produce greater antinociception in male monkeys than in females, and the magnitude of these sex-related differences may be inversely related to efficacy at mu receptors or selectivity for mu versus kappa receptors. Estradiol appears to have little effect on mu-agonist antinociception in primates but may enhance the antinociceptive effects of kappa agonists.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
290
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1132-40
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10454487-3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-ben..., pubmed-meshheading:10454487-Analgesics, Non-Narcotic, pubmed-meshheading:10454487-Analgesics, Opioid, pubmed-meshheading:10454487-Animals, pubmed-meshheading:10454487-Dose-Response Relationship, Drug, pubmed-meshheading:10454487-Estradiol, pubmed-meshheading:10454487-Estrogen Replacement Therapy, pubmed-meshheading:10454487-Female, pubmed-meshheading:10454487-Hot Temperature, pubmed-meshheading:10454487-Macaca mulatta, pubmed-meshheading:10454487-Male, pubmed-meshheading:10454487-Nociceptors, pubmed-meshheading:10454487-Ovariectomy, pubmed-meshheading:10454487-Pain, pubmed-meshheading:10454487-Receptors, Opioid, kappa, pubmed-meshheading:10454487-Receptors, Opioid, mu, pubmed-meshheading:10454487-Sex Factors
pubmed:year
1999
pubmed:articleTitle
Opioid antinociception in ovariectomized monkeys: comparison with antinociception in males and effects of estradiol replacement.
pubmed:affiliation
Alcohol and Drug Abuse Research Center, Harvard Medical School-McLean Hospital, Belmont, Massachusetts, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.