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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1999-9-9
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pubmed:abstractText |
After initial seeding by thymic emigrants, homeostatic regulation of the T cell pool has been thought to occur entirely within the periphery. Here we report that the degree of thymic emigration directly affects the number and the CD4/CD8 ratio of peripheral T cells. We demonstrate that the increase in T cell pool size caused by the engraftment of 2, 6, or 9 thymic lobes correlates almost exactly with the number of emigrants exported from those grafts in the previous 3 weeks, regardless of how long the graft has been in place. The extent of the increase supports the concept of a 3-week period after thymic export in which emigrant T cells are exempt from peripheral T cell homeostasis. This apparent exclusion of recent thymic emigrants from the niche-based regulation of peripheral T cell numbers ensures repertoire turnover throughout adult life and provides the basis of a direct and previously unrecognized role for the thymus in the regulation of peripheral T cell homeostasis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-10227982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-1684776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-2500349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-2860976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-3100624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-310804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-4945475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-6606619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-7379836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-7539027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-7545110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-7622868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-7790023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8073282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8094457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8145034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8258683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8569276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8600538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8601219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8658161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8808677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8854558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8921950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-8962629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9067539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9197272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9203411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9314558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9334361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9334366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9394828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9405261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9405262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9405263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9405265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9476668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9535647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9551963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9558071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9607924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449772-9645370
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9787-91
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10449772-Animals,
pubmed-meshheading:10449772-Apoptosis,
pubmed-meshheading:10449772-CD4-CD8 Ratio,
pubmed-meshheading:10449772-Cells, Cultured,
pubmed-meshheading:10449772-Homeostasis,
pubmed-meshheading:10449772-Lymphocyte Count,
pubmed-meshheading:10449772-Mice,
pubmed-meshheading:10449772-Mice, Inbred C57BL,
pubmed-meshheading:10449772-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:10449772-T-Lymphocytes,
pubmed-meshheading:10449772-Thymus Gland
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pubmed:year |
1999
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pubmed:articleTitle |
A central role for thymic emigrants in peripheral T cell homeostasis.
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pubmed:affiliation |
Department of Pathology and Immunology, Monash Medical School, Commercial Road, Prahran, Victoria 3181, Australia. berzins@med.monash.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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