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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-9-9
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pubmed:abstractText |
To further enhance chimerism, 229 primary allograft recipients have received perioperative intravenous infusion of a single dose of 3 to 6 X 10(8) unmodified donor bone marrow (BM) cells/kg body weight. In addition, 42 patients have been accrued in a concurrent protocol involving multiple (up to three) sequential perioperative infusions of 2 x 10(8) BM cells/kg/day from day 0-2 posttransplantation (PTx). Organ recipients (n = 133) for whom BM was not available were monitored as controls. The infusion of BM was safe and except for 50 (18%), all study patients have optimal graft function. Of the control patients, allografts in 30 (23%) have been lost during the course of follow-up. The cumulative risk of acute cellular rejection (ACR) was statistically lower in the study patients compared with that of controls. It is interesting that, 62% of BM-augmented heart recipients were free of ACR (Grade > or = 3A) in the first 6 months PTx compared to controls. The incidence of obliterative bronchiolitis was also statistically lower in study lung recipients (3.8%) compared with the contemporaneously acquired controls (31%). The levels of donor cell chimerism were at least a log higher in the peripheral blood of majority of the study patients compared with that of controls. The incidence of donor-specific hyporeactivity, as determined by one-way mixed leukocyte reaction, was also higher in those BM-augmented liver, kidney, and lung recipients that could be evaluated compared to controls.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-13099277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-1351558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-14066188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-14414715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-1714104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-1951452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-2247151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-49564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-7505503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-7912764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-8991290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10449174-9862947
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0741-5400
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pubmed:author |
pubmed-author:Abu-ElmagdKK,
pubmed-author:CorsiCC,
pubmed-author:DodsonFF,
pubmed-author:FungJ JJJ,
pubmed-author:GriffithBB,
pubmed-author:JordanMM,
pubmed-author:KeenanRR,
pubmed-author:McCurryKK,
pubmed-author:OstrowskiLL,
pubmed-author:PhamSS,
pubmed-author:RaoA SAS,
pubmed-author:ReyesJJ,
pubmed-author:SalgarS KSK,
pubmed-author:SesliEE,
pubmed-author:ShapiroRR,
pubmed-author:StarzlT ETE,
pubmed-author:ZeeviAA
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pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
310-4
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pubmed:dateRevised |
2011-7-22
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pubmed:meshHeading |
pubmed-meshheading:10449174-Bone Marrow Cells,
pubmed-meshheading:10449174-Bone Marrow Transplantation,
pubmed-meshheading:10449174-Female,
pubmed-meshheading:10449174-Follow-Up Studies,
pubmed-meshheading:10449174-Graft Rejection,
pubmed-meshheading:10449174-Heart Transplantation,
pubmed-meshheading:10449174-Herpesvirus 4, Human,
pubmed-meshheading:10449174-Humans,
pubmed-meshheading:10449174-Immune Tolerance,
pubmed-meshheading:10449174-Incidence,
pubmed-meshheading:10449174-Kidney Transplantation,
pubmed-meshheading:10449174-Leukocyte Transfusion,
pubmed-meshheading:10449174-Leukocytes,
pubmed-meshheading:10449174-Liver Transplantation,
pubmed-meshheading:10449174-Lung Transplantation,
pubmed-meshheading:10449174-Lymphoproliferative Disorders,
pubmed-meshheading:10449174-Organ Transplantation,
pubmed-meshheading:10449174-Transplantation, Homologous,
pubmed-meshheading:10449174-Transplantation Chimera
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pubmed:year |
1999
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pubmed:articleTitle |
Infusion of donor leukocytes to induce tolerance in organ allograft recipients.
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pubmed:affiliation |
Thomas E. Starzl Transplantation Institute and the Department of Surgery, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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