Linked Life Data

10445154

Source:http://linkedlifedata.com/resource/pubmed/id/10445154

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-9-22
pubmed:abstractText
Multipotential (osteogenic, adipogenic, chondrogenic, and myelosupportive) cells associated with the bone marrow stroma are revealed by in vitro or in vivo differentiation assays. If considered in the context of development, growth, and adaptive changes of bone as an organ, the hierarchical organization, histophysiology, and biological significance of the so-called "stromal system" appear distinct from those predicted from the commonly used analogy with the hematopoietic system, with which the stromal system and its putative "stem" cell are usually compared. The plasticity of differentiated phenotypes and the emergence of individual lineages in a defined temporal succession throughout development and postnatal life reflect the role of the multipotential cells in the stromal system in tissue adaptation and growth, rather than in cell consumption and replacement. This makes the stromal system and its progenitors an interesting paradigm of the biology of an individual cell's flexibility in complex organisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1045-4403
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-73
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Multipotential cells in the bone marrow stroma: regulation in the context of organ physiology.
pubmed:affiliation
Dipartimento di Medicina Sperimentale, Università dell'Aquila, Italy.
pubmed:publicationType
Journal Article, Review