Linked Life Data

10444660

Source:http://linkedlifedata.com/resource/pubmed/id/10444660

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-9-23
pubmed:abstractText
The ability of 17 cats to discriminate floor temperatures 2-4 degrees C below the ambient temperature was tested before and after unilateral electrolytic thalamic lesions. The lesions were made contralateral to the paws showing better performance in the temperature discrimination task. They were aimed at one or more of the three main target areas of thermoreceptive-specific lamina I spinothalamic neurons [i.e., the nucleus submedius, the dorsomedial aspect of the ventral posterior medial nucleus, and the ventral aspect of the basal ventral medial nucleus (vVMb)], following microelectrode mapping of somatosensory thalamus. The thermosensory consequences of each lesion were measured in postoperative testing, beginning 6-8 days after the final preoperative test session. A mild but definite thermosensory deficiency was found in five cats, in which the response behavior on the contralateral side was reduced below the 69% criterion level for several sessions. Histological analysis indicated that these cats differed only by the inclusion in the lesion of all or part of vVMb. Consequently this area appears to be important for cats' thermosensory behavior. Nevertheless even large lesions of virtually all of the thermoreceptive lamina I spinothalamic projection areas produced only this mild thermosensory deficit in stark contrast with the massive defect observed previously after spinal lesions of the middle of the lateral funiculus, where lamina I axons ascend. Accordingly such spinal lesions were added at the C(4) level, on the same side as the thalamic lesions, in six cats 3 mo after the thalamic surgery. These lesions caused severe contralateral defects (i.e., chance level performance). Thus the present findings are taken to indicate that contralateral ascending projections to vVMb in the thalamus participate in cats' thermosensory discrimination but that ascending projections to the brain stem must play an important role in their behavioral thermosensitivity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-3077
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-25
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Behavioral thermosensitivity after lesions of thalamic target areas of a thermosensory spinothalamic pathway in the cat.
pubmed:affiliation
Department of Physiology, Göteborg University, SE 40530 Göteborg, Sweden.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't