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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1999-9-7
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pubmed:databankReference |
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pubmed:abstractText |
Developing Dictyostelium cells form large aggregation streams that break up into groups of 0.2 x 10(5) to 1 x 10(5) cells. Each group then becomes a fruiting body. smlA cells oversecrete an unknown factor that causes aggregation streams to break up into groups of approximately 5 x 10(3) cells and thus form very small fruiting bodies. We have purified the counting factor and find that it behaves as a complex of polypeptides with an effective molecular mass of 450 kD. One of the polypeptides is a 40-kD hydrophilic protein we have named counting. In transformants with a disrupted counting gene, there is no detectable secretion of counting factor, and the aggregation streams do not break up, resulting in huge (up to 2 x 10(5) cell) fruiting bodies.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-13139286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-1328260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-1332700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-14039462,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-185228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-222338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-222583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-230476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-2536338,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-2847151,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-3093890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-3298996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-4322968,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-6265098,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-8787732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-8951083,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10444594-9654007
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0890-9369
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1960-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10444594-Amino Acid Sequence,
pubmed-meshheading:10444594-Animals,
pubmed-meshheading:10444594-Base Sequence,
pubmed-meshheading:10444594-Cell Aggregation,
pubmed-meshheading:10444594-Cell Count,
pubmed-meshheading:10444594-Cloning, Molecular,
pubmed-meshheading:10444594-Culture Media, Conditioned,
pubmed-meshheading:10444594-Dictyostelium,
pubmed-meshheading:10444594-Molecular Sequence Data,
pubmed-meshheading:10444594-Molecular Weight,
pubmed-meshheading:10444594-Mutation,
pubmed-meshheading:10444594-Phenotype,
pubmed-meshheading:10444594-Protein Sorting Signals,
pubmed-meshheading:10444594-Protozoan Proteins,
pubmed-meshheading:10444594-RNA, Messenger,
pubmed-meshheading:10444594-Sequence Analysis,
pubmed-meshheading:10444594-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
A cell-counting factor regulating structure size in Dictyostelium.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biochemistry and Cell Biology MS-140, Rice University, Houston, Texas 77005-1892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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