Source:http://linkedlifedata.com/resource/pubmed/id/10443679
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1999-8-19
|
| pubmed:abstractText |
Insulin-like growth factor I (IGF-I) is a major regulator of bone growth during childhood. However, beyond knowledge that IGF-I influences longitudinal growth, its associations to changes in the cross-sectional dimensions, the volume, or the material density of bone during growth are unknown. We assessed the relationships between serum IGF-I and measurements of cross-sectional area, cortical bone area, and cortical bone density at the midshaft of the femur in 197 normal healthy white children and adolescents (103 boys and 94 girls; aged 7.8-18.2 yr). Bone determinations were obtained using computed tomography, and levels of IGF-I were measured by RIA after an extraction procedure. IGF-I correlated significantly with both cross-sectional area (r = 0.49; P < 0.0001) and cortical bone area (r = 0.50; P < 0.0001), but did not correlate with the material density of cortical bone (r = -0.08). Multiple regression analyses showed that circulating levels of IGF-I were associated with cross-sectional area (P = 0.03) and cortical bone area (P = 0.04) values, even after correcting for the confounding effects of age, gender, weight, and femoral length. We conclude that IGF-I is a major determinant of the cross-sectional properties of bone, but does not influence the material density of bone, in the appendicular skeleton.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
84
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2780-3
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10443679-Adolescent,
pubmed-meshheading:10443679-Bone Density,
pubmed-meshheading:10443679-Bone and Bones,
pubmed-meshheading:10443679-Child,
pubmed-meshheading:10443679-Female,
pubmed-meshheading:10443679-Humans,
pubmed-meshheading:10443679-Insulin-Like Growth Factor I,
pubmed-meshheading:10443679-Male,
pubmed-meshheading:10443679-Regression Analysis,
pubmed-meshheading:10443679-Tomography, X-Ray Computed
|
| pubmed:year |
1999
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| pubmed:articleTitle |
Serum levels of insulin-like growth factor I and the density, volume, and cross-sectional area of cortical bone in children.
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| pubmed:affiliation |
Department of Radiology, Children's Hospital, Los Angeles, California 90027, USA.
|
| pubmed:publicationType |
Journal Article
|