Linked Life Data

10441655

Source:http://linkedlifedata.com/resource/pubmed/id/10441655

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-10-7
pubmed:abstractText
A high sucrose diet and glucocorticoid medication reduced dentine formation in molars of growing rats. This study was undertaken to determine whether the treatment schedules could have produced commensurate reductions in dentine minerals, and the particular concentrations of calcium (Ca) and phosphorus (P). Forty Spraque-Dawley rats were weaned at the age of 3 weeks. Tetracycline was injected i.p. to produce a fluorescent line which demarcated the preweaning from the postweaning dentine. The animals were then divided into two groups. Control rats were fed a commercial rat chow, test animals were fed a 43% sucrose diet. Half the animals in each group were also subjected to surgical implantation (s.c.) of cortisone pellets which released 0.42 mg into the circulation over a 24-hour period. At the end of the 6 week trials rats were killed and the mandibles were defleshed and prepared for electron probe microanalyzer. Each animal served as its own control, as the content of Ca, P, and total minerals were analyzed in the pre- and postweaning regions of dentine. During the preweaning there were no differences between the groups in any minerals. There was a slight reduction of minerals during the postweaning compared with the preweaning. During the postweaning, the sucrose diet significantly reduced the amount of Ca, P, and total minerals compared with the preweaning. During the postweaning, the sucrose diet reduced Ca compared with glucocorticoid medication and total minerals compared with other groups. On the contrary glucocorticoid medication seemed to compensate the reduction of minerals induced by the sucrose diet.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0171-967X
pubmed:author
pubmed:issnType
Print
pubmed:volume
65
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
An electron probe x-ray microanalytical study of dentine minerals in sucrose-fed or glucocorticoid-medicated rats.
pubmed:affiliation
Institute of Dentistry, University of Oulu, Finland.
pubmed:publicationType
Journal Article