Linked Life Data

10436534

Source:http://linkedlifedata.com/resource/pubmed/id/10436534

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-10-14
pubmed:abstractText
The local availability of growth factors and oxygen plays an important role in the healing of cutaneous lesions. We were able to quantify the ischemia in a standardized ischemic full-wall flap by measuring the ptiO2, and investigate the healing of defined wounds. The analysis of the immune histochemical section showed a significantly reduced expression of IGF-I in the wound edge of ischemic wounds. Simultaneously the rate of proliferation was reduced here. Probably the local chronic hypoxia leads to reduced IGF-I synthesis and thus to reduced proliferation and delayed wound healing. Further investigation is necessary to confirm this hypothesis. In a clinical study of wounds which had been treated with vacuum sealing we could establish no difference in the concentration of IGF-I in the wound fluid of seriously contaminated wounds in comparison to primary fasciotomy wounds. We therefore postulate a primary endocrinal secretion for IGF-I in cases of cutaneous wound healing; higher local consumption or reduced serum levels could stimulate the autocrinal local secretion of IGF-I. Further investigation is, however, needed in order to confirm this hypothesis.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-409X
pubmed:author
pubmed:issnType
Print
pubmed:volume
124 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
78-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
[Temporary expression pattern in wound secretions and peripheral wound biopsies].
pubmed:affiliation
Abteilung für Allgemeine Chirurgie und Poliklinik, Chirurgische Universitätsklinik Tübingen.
pubmed:publicationType
Journal Article, English Abstract