Linked Life Data

10433800

Source:http://linkedlifedata.com/resource/pubmed/id/10433800

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pubmed-article:10433800pubmed:abstractTextNumerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a member of the adamalysin class of zinc-binding metalloproteases or ADAM (a disintegrin and metalloprotease). We report the isolation and characterization of the mouse TACE/ADAM17 cDNA and gene. Mouse TACE/ADAM17 has a 92% amino-acid identity with the human protein and was ubiquitously expressed. A recombinant form of the protease is found to cleave a peptide representing the cleavage site of precursor mouse TNF-alpha. An alternatively spliced form of mouse TACE/ADAM17 was found that would produce a soluble protein. The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25.lld:pubmed
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pubmed-article:10433800pubmed:authorpubmed-author:CopelandN GNGlld:pubmed
pubmed-article:10433800pubmed:authorpubmed-author:GilbertD JDJlld:pubmed
pubmed-article:10433800pubmed:authorpubmed-author:CastnerB JBJlld:pubmed
pubmed-article:10433800pubmed:authorpubmed-author:JenkinsN ANAlld:pubmed
pubmed-article:10433800pubmed:authorpubmed-author:CerrettiD PDPlld:pubmed
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pubmed-article:10433800pubmed:copyrightInfoCopyright 1999 Academic Press.lld:pubmed
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pubmed-article:10433800pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:10433800pubmed:articleTitleCharacterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25.lld:pubmed
pubmed-article:10433800pubmed:affiliationImmunex Corporation, 51 University St., Seattle, WA, 98101, USA. cerretti@immunex.comlld:pubmed
pubmed-article:10433800pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10433800pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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