| pubmed-article:10417761 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C0022173 | lld:lifeskim |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C1709160 | lld:lifeskim |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10417761 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10417761 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10417761 | pubmed:dateCreated | 1999-8-13 | lld:pubmed |
| pubmed-article:10417761 | pubmed:abstractText | Expression of prostaglandin-H-synthase (PGHS) isozymes was analyzed in 50 biopsies of normal human skin and of pre-malignant and malignant skin lesions, by means of quantitative RT-PCR, immunoprecipitation and Western blotting, as well as immunohistochemistry. Normal skin constitutively expressed PGHS-1 in all cell layers of the epidermis, in endothelial cells of small blood vessels and in sweat-gland epithelium. PGHS-2 expression was very low and restricted to a few keratinocytes of the interfollicular and follicular epidermis. Steady-state concentrations of PGHS-1 and PGHS-2 mRNA were similar in normal skin and in basal-cell carcinomas, but PGHS-1 mRNA was reduced and PGHS-2 mRNA was elevated in actinic keratoses, squamous-cell carcinomas and keratoacanthomas. PGHS-1 protein was detected in all tumor biopsies, being occasionally increased in basal-cell carcinomas. High amounts of PGHS-2 protein were found in actinic keratoses, squamous-cell carcinomas and keratoacanthomas, but not in basal-cell carcinomas. Four malignant melanomas included in this study contained PGHS-1 but no PGHS-2 protein. Immunohistochemical analysis of the biopsies identified keratinocytes, in addition to cells of inflammatory infiltrates and of dendritic morphology, as the major PGHS-expressing cell types. PGHS-2-specific signals were spread throughout the epidermal part of actinic keratoses and squamous-cell carcinomas. These data suggest that constitutive up-regulation of PGHS-2 expression is a consistent pre-malignant event in squamous-cell cancer development in man, as it is in animal models of skin carcinogenesis. Thus, pre-cancerous lesions such as actinic keratoses present a likely target for chemoprevention of skin cancer by selective PGHS-2 inhibitors. | lld:pubmed |
| pubmed-article:10417761 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10417761 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10417761 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10417761 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10417761 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10417761 | pubmed:issn | 0020-7136 | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:ZimmermannRR | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:HeiseHH | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:MarksFF | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:Fürstenberger... | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:KriegPP | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:BayerlCC | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:Müller-Decker... | lld:pubmed |
| pubmed-article:10417761 | pubmed:author | pubmed-author:ReinerthGG | lld:pubmed |
| pubmed-article:10417761 | pubmed:copyrightInfo | Copyright 1999 Wiley-Liss, Inc. | lld:pubmed |
| pubmed-article:10417761 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10417761 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:10417761 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:10417761 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10417761 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10417761 | pubmed:pagination | 648-56 | lld:pubmed |
| pubmed-article:10417761 | pubmed:dateRevised | 2007-7-24 | lld:pubmed |
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| pubmed-article:10417761 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10417761 | pubmed:articleTitle | Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. | lld:pubmed |
| pubmed-article:10417761 | pubmed:affiliation | Research Program, Tumor Cell Regulation, Deutsches Krebsforschungszentrum, Heidelberg, Germany. K.Mueller-Decker@DKFZ-Heidelberg.de | lld:pubmed |
| pubmed-article:10417761 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10417761 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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