Linked Life Data

10416833

Source:http://linkedlifedata.com/resource/pubmed/id/10416833

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pubmed-article:10416833pubmed:abstractTextWe studied the expression level and cell-specific expression patterns of 5alpha-reductase (5alpha-R) types 1 and 2 iso-enzymes in human hyperplastic and malignant prostate tissue by semi-quantitative RT-PCR and in situ hybridisation analyses. In situ hybridisation established that 5alpha-R1 mRNA is preferentially expressed by epithelial cells and little expressed by stromal cells whereas 5alpha-R2 mRNA is expressed by both epithelium and stroma. Semi-quantitative RT-PCR has been performed on total RNA from different zones of normal prostate, BPH tissues and liver. We found that 5alpha-R1 and 5alpha-R2 mRNAs expression was near the same in all zones of normal prostate. In BPH tissue, 5alpha-R1 and 5alpha-R2 mRNAs expression was slightly but significantly increased, when it was compared to the levels recorded for normal prostate. In cancer samples, 5alpha-R1 mRNA expression was higher than in normal and hyperplastic prostate but the level of 5alpha-R2 mRNA was not statistically different from that observed in the different zones of normal prostate. In liver, 5alpha-R2 mRNA level was similar to that measured in BPH but 5alpha-R1 mRNA expression was ten times higher. The increase observed in 5alpha-R isoenzymes expression in BPH tissue could play an important role in the pathogenesis and/or maintenance of the disease.lld:pubmed
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pubmed-article:10416833pubmed:authorpubmed-author:GérardHHlld:pubmed
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pubmed-article:10416833pubmed:authorpubmed-author:Gil Diez de...lld:pubmed
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pubmed-article:10416833pubmed:pagination189-95lld:pubmed
pubmed-article:10416833pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:10416833pubmed:year1999lld:pubmed
pubmed-article:10416833pubmed:articleTitleDifferences in steroid 5alpha-reductase iso-enzymes expression between normal and pathological human prostate tissue.lld:pubmed
pubmed-article:10416833pubmed:affiliationLaboratoire de Cancérologie Expérimentale, INSERM CJF 93-11, Faculté de Médecine Nord, Marseille, France.lld:pubmed
pubmed-article:10416833pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:10416833pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:10416833pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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