Source:http://linkedlifedata.com/resource/pubmed/id/10416585
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
1999-8-12
|
| pubmed:abstractText |
Several epidemiological studies have indicated that female tobacco smokers may be at higher risk of lung cancer than males. In a study of lung cancer cases, we have found that female smokers had a significantly higher level of aromatic/hydrophobic DNA adducts in their nontumor lung tissue (15.39+/-9.47 adducts/10(8) nucleotides, n = 29) than male smokers (12.08+/-8.14, a = 93; P = 0.047). Females had significantly higher levels of adducts/pack-year (females 0.95+/-0.82 adducts/pack-year and males 0.46+/-0.46; P = 0.0004) and adducts/cigaret/day (females 1.48+/-1.29 and males 0.89+/-0.74, P = 0.015). By quantitative reverse transcription-PCR, it was found that female smokers exhibited a significantly higher expression level of lung CYP1A1 (494+/-334 CYP1A1 mRNA/10(6) glyceraldehyde-3-phophate dehydrogenase mRNA, n = 15) compared with males (210+/-208, n = 12; P = 0.016). Furthermore, for both sexes combined a significant correlation between CYP1A1 expression and DNA adduct level was found (r = 0.50, P = 0.009). In conclusion, the observed sex difference in aromatic/hydrophobic DNA adduct levels may at least in part be explained by different levels of CYP1A1 expression.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Adducts,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroso Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Polycyclic Hydrocarbons, Aromatic
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0008-5472
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
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| pubmed:volume |
59
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3317-20
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10416585-Adult,
pubmed-meshheading:10416585-Aged,
pubmed-meshheading:10416585-Cytochrome P-450 CYP1A1,
pubmed-meshheading:10416585-DNA,
pubmed-meshheading:10416585-DNA, Neoplasm,
pubmed-meshheading:10416585-DNA Adducts,
pubmed-meshheading:10416585-Enzyme Induction,
pubmed-meshheading:10416585-Female,
pubmed-meshheading:10416585-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10416585-Humans,
pubmed-meshheading:10416585-Lung Neoplasms,
pubmed-meshheading:10416585-Male,
pubmed-meshheading:10416585-Middle Aged,
pubmed-meshheading:10416585-Neoplasm Proteins,
pubmed-meshheading:10416585-Nitroso Compounds,
pubmed-meshheading:10416585-Polycyclic Hydrocarbons, Aromatic,
pubmed-meshheading:10416585-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10416585-Smoking
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| pubmed:year |
1999
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| pubmed:articleTitle |
Sex differences in lung CYP1A1 expression and DNA adduct levels among lung cancer patients.
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| pubmed:affiliation |
Department of Toxicology, National Institute of Occupational Health, Oslo, Norway. Steen.Mollerup@stami.no
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|