Linked Life Data

10407135

Source:http://linkedlifedata.com/resource/pubmed/id/10407135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-9-13
pubmed:databankReference
pubmed:abstractText
We have identified and characterized a new member of the mammalian brain-specific T-box gene family, Tbr2, which is closely related to mouse Tbr1, and to the Xenopus earliest mesodermal gene, Eomesodermin. As Tbr1, Tbr2 is predominantly expressed in some regions of the developing brain, but in a strikingly complementary manner. On embryonic day 14.5 (E14.5), Tbr2 mRNA expression was observed in the mesencephalon and rhombencephalon in contrast to Tbr1 which was expressed mostly in the telencephalon. At this stage, Tbr2 mRNA was readily detectable in the postmitotic and differentiating neurons located in various brain regions, i.e., oculomotor, red, trigeminal, vestibular, facial, and hypoglossal nuclei. However, expression of Tbr2 in these nuclei became undetectable on E18.5. In contrast, Tbr2 mRNA expression was detected in the hippocampus only from E18.5 onwards. Whereas Tbr2 expression disappeared in most parts of the mature adult brain, it remained detectable in the hippocampus and olfactory bulb, regions where some neuronal precursors retain their differentiation potential. These results suggest that Tbr2 may play a crucial role in differentiating neurons rather than in proliferating or already differentiated neurons. In addition, similarly to Xenopus Eomesodermin, mouse Tbr2 showed biphasic expression; a first peak around E6.5 and a second peak around E14.5, suggesting that Tbr2 may also be important at early stages of gastrulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0165-3806
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Elsevier Science B.V.
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-93
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain.
pubmed:affiliation
Department of Molecular Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't