|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003765,
umls-concept:C0051326,
umls-concept:C0205531,
umls-concept:C0226896,
umls-concept:C0243076,
umls-concept:C0332256,
umls-concept:C0442027,
umls-concept:C0920591,
umls-concept:C0935763,
umls-concept:C1138427,
umls-concept:C1527415
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|
pubmed:issue |
13
|
|
pubmed:dateCreated |
1999-10-14
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|
pubmed:abstractText |
A peptide RGD analog containing a novel 2-aminopyridine arginine mimetic was discovered to have good affinity and selectivity for the vitronectin receptor. Incorporation of the 2-aminopyridine arginine mimetic into the 3-oxo-1,4-benzodiazepine-2-acetic acid integrin antagonist series led to novel and potent nonpeptide vitronectin receptor antagonists with promising levels of oral bioavailability.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
pubmed-author:BartonL SLS,
pubmed-author:BondinellW EWE,
pubmed-author:CousinsR DRD,
pubmed-author:EppleyD FDF,
pubmed-author:HwangS MSM,
pubmed-author:KeenanR MRM,
pubmed-author:KwonCC,
pubmed-author:LohrJ TJT,
pubmed-author:MillerW HWH,
pubmed-author:NguyenT TTT,
pubmed-author:SmithB RBR,
pubmed-author:UzinskasI NIN,
pubmed-author:YuanC CCC
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|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1801-6
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|
pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:10406645-Administration, Oral,
pubmed-meshheading:10406645-Aminopyridines,
pubmed-meshheading:10406645-Animals,
pubmed-meshheading:10406645-Arginine,
pubmed-meshheading:10406645-Biological Availability,
pubmed-meshheading:10406645-Dogs,
pubmed-meshheading:10406645-Kinetics,
pubmed-meshheading:10406645-Rats,
pubmed-meshheading:10406645-Receptors, Vitronectin
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|
pubmed:year |
1999
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|
pubmed:articleTitle |
Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics.
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|
pubmed:affiliation |
Research & Development Division, SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA.
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pubmed:publicationType |
Journal Article
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