Linked Life Data

10403542

Source:http://linkedlifedata.com/resource/pubmed/id/10403542

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-8-19
pubmed:abstractText
The post-initiation stage of hepatocarcinogenesis was investigated in carcinogen-resistant inbred DRH rats and the parental strain, carcinogen-sensitive Donryu rats. Male rats at 5 weeks of age from both strains were treated with N-nitrosodiethylamine (200 mg/kg i.p.) followed by feeding with a diet containing 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) from 2 weeks later and were then subjected to partial hepatectomy at 1 week later. At 8 weeks after the start of treatment, the mean area occupied by glutathione S-transferase placental form (GST-P)-positive lesions was about 30% in Donryu rats but less than 4% in DRH rats despite the presence of comparable numbers of foci in the livers of both strains. These observations suggested that clonal expansion of GST-P-positive foci in DRH rat liver was significantly suppressed under these conditions. Furthermore, this genetic property was dominantly inherited in the F1 rats by crosses of DRH and carcinogen-sensitive inbred F344 rats; that is, the induction of GST-P mRNA in the livers of F344 x DRH F1 rats was dominantly suppressed after administration of 3'-Me-DAB for 8 weeks as compared with parental F344 rats under the same conditions. We compared the intrinsic properties related to growth potential of liver cells between adult DRH and Donryu rats. DRH rat liver showed retarded and/or reduced DNA synthesis after partial hepatectomy or a single i.v. injection of lead nitrate and lower activity of telomerase induced by 3'-Me-DAB administration for 1 week, as compared with the Donryu rat liver. The intrinsic properties observed in this study may be related, at least in part, to the low incidence of liver tumors induced by hepatocarcinogens in DRH rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-67
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:10403542-Animals, pubmed-meshheading:10403542-Blotting, Northern, pubmed-meshheading:10403542-Body Weight, pubmed-meshheading:10403542-Cell Division, pubmed-meshheading:10403542-Crosses, Genetic, pubmed-meshheading:10403542-DNA, pubmed-meshheading:10403542-Diethylnitrosamine, pubmed-meshheading:10403542-Glutathione Transferase, pubmed-meshheading:10403542-Hepatectomy, pubmed-meshheading:10403542-Lead, pubmed-meshheading:10403542-Liver Neoplasms, Experimental, pubmed-meshheading:10403542-Male, pubmed-meshheading:10403542-Methyldimethylaminoazobenzene, pubmed-meshheading:10403542-Nitrates, pubmed-meshheading:10403542-Organ Size, pubmed-meshheading:10403542-Precancerous Conditions, pubmed-meshheading:10403542-RNA, Messenger, pubmed-meshheading:10403542-Rats, pubmed-meshheading:10403542-Rats, Inbred F344, pubmed-meshheading:10403542-Rats, Inbred Strains, pubmed-meshheading:10403542-Telomerase
pubmed:year
1999
pubmed:articleTitle
Genetic properties for the suppression of development of putative preneoplastic glutathione S-transferase placental form-positive foci in the liver of carcinogen-resistant DRH strain rats.
pubmed:affiliation
Department of Oncological Pathology, Cancer Center, Nara Medical University, Kashiwara, Japan.
pubmed:publicationType
Journal Article, Comparative Study