Linked Life Data

10399341

Source:http://linkedlifedata.com/resource/pubmed/id/10399341

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1999-7-22
pubmed:abstractText
The interaction of 15 steroidal drugs with a water-soluble beta-cyclodextrin polymer was studied by reversed-phase thin-layer chromatography in the absence and in the presence of 0.1 M sodium chloride. The relative strength of interaction was calculated and the relationship between the hydrophobicity parameters of the drugs and the strength of the drug-beta-cyclodextrin polymer was elucidated by principal component analysis. Drugs readily formed inclusion complexes with the cyclodextrin derivatives; the strength of the interaction was higher in the presence of sodium chloride. It was assumed that the formation of inclusion complexes may influence the behaviour of the drugs resulting in modified biological efficacy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9673
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
845
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
447-53
pubmed:dateRevised
2009-1-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Interaction of some steroid drugs with beta-cyclodextrin polymer.
pubmed:affiliation
Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Budapest, Hungary. forgacs@cric.chemres.hu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't