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pubmed:abstractText |
The synthesis of the 1-amino derivative of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid (1-amino-APDC), a selective metabotropic glutamate ligand, is disclosed. This compound acts as a partial agonist of the group II mGluRs and shows pronounced neuroprotective properties in the NMDA model of cell toxicity.
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pubmed:affiliation |
Georgetown University Medical Center, Drug Discovery Laboratory, Institute for Cognitive & Computational Sciences, Washington, DC 20007-2197, USA.
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